SubstanceSpecification.xml
   1 <?xml version="1.0" encoding="utf-8"?>
   2 <StructureDefinition xmlns="http://hl7.org/fhir">
   3   <id value="SubstanceSpecification" />
   4   <meta>
   5     <lastUpdated value="2019-10-31T23:29:23.356+01:00" />
   6   </meta>
   7   <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-category">
   8     <valueString value="Specialized.Medication Definition" />
   9   </extension>
  10   <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status">
  11     <valueCode value="trial-use" />
  12   </extension>
  13   <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm">
  14     <valueInteger value="0" />
  15   </extension>
  16   <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-security-category">
  17     <valueCode value="anonymous" />
  18   </extension>
  19   <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-wg">
  20     <valueCode value="brr" />
  21   </extension>
  22   <url value="http://hl7.org/fhir/StructureDefinition/SubstanceSpecification" />
  23   <version value="4.0.1" />
  24   <name value="SubstanceSpecification" />
  25   <status value="draft" />
  26   <date value="2019-10-31T23:29:23.0000000+01:00" />
  27   <publisher value="Health Level Seven International (Biomedical Research and Regulation)" />
  28   <contact>
  29     <telecom>
  30       <system value="url" />
  31       <value value="http://hl7.org/fhir" />
  32     </telecom>
  33   </contact>
  34   <contact>
  35     <telecom>
  36       <system value="url" />
  37       <value value="http://www.hl7.org/Special/committees/rcrim/index.cfm" />
  38     </telecom>
  39   </contact>
  40   <description value="The detailed description of a substance, typically at a level beyond what is used for prescribing." />
  41   <fhirVersion value="4.0.1" />
  42   <mapping>
  43     <identity value="rim" />
  44     <uri value="http://hl7.org/v3" />
  45     <name value="RIM Mapping" />
  46   </mapping>
  47   <kind value="resource" />
  48   <abstract value="false" />
  49   <type value="SubstanceSpecification" />
  50   <baseDefinition value="http://hl7.org/fhir/StructureDefinition/DomainResource" />
  51   <derivation value="specialization" />
  52   <snapshot>
  53     <element id="SubstanceSpecification">
  54       <path value="SubstanceSpecification" />
  55       <short value="The detailed description of a substance, typically at a level beyond what is used for prescribing" />
  56       <definition value="The detailed description of a substance, typically at a level beyond what is used for prescribing." />
  57       <min value="0" />
  58       <max value="*" />
  59       <base>
  60         <path value="SubstanceSpecification" />
  61         <min value="0" />
  62         <max value="*" />
  63       </base>
  64       <constraint>
  65         <key value="dom-2" />
  66         <severity value="error" />
  67         <human value="If the resource is contained in another resource, it SHALL NOT contain nested Resources" />
  68         <expression value="contained.contained.empty()" />
  69         <xpath value="not(parent::f:contained and f:contained)" />
  70         <source value="http://hl7.org/fhir/StructureDefinition/DomainResource" />
  71       </constraint>
  72       <constraint>
  73         <key value="dom-3" />
  74         <severity value="error" />
  75         <human value="If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource" />
  76         <expression value="contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()" />
  77         <xpath value="not(exists(for $id in f:contained/*/f:id/@value return $contained[not(parent::*/descendant::f:reference/@value=concat('#', $contained/*/id/@value) or descendant::f:reference[@value='#'])]))" />
  78         <source value="http://hl7.org/fhir/StructureDefinition/DomainResource" />
  79       </constraint>
  80       <constraint>
  81         <key value="dom-4" />
  82         <severity value="error" />
  83         <human value="If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated" />
  84         <expression value="contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()" />
  85         <xpath value="not(exists(f:contained/*/f:meta/f:versionId)) and not(exists(f:contained/*/f:meta/f:lastUpdated))" />
  86         <source value="http://hl7.org/fhir/StructureDefinition/DomainResource" />
  87       </constraint>
  88       <constraint>
  89         <key value="dom-5" />
  90         <severity value="error" />
  91         <human value="If a resource is contained in another resource, it SHALL NOT have a security label" />
  92         <expression value="contained.meta.security.empty()" />
  93         <xpath value="not(exists(f:contained/*/f:meta/f:security))" />
  94         <source value="http://hl7.org/fhir/StructureDefinition/DomainResource" />
  95       </constraint>
  96       <constraint>
  97         <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bestpractice">
  98           <valueBoolean value="true" />
  99         </extension>
 100         <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bestpractice-explanation">
 101           <valueMarkdown value="When a resource has no narrative, only systems that fully understand the data can display the resource to a human safely. Including a human readable representation in the resource makes for a much more robust eco-system and cheaper handling of resources by intermediary systems. Some ecosystems restrict distribution of resources to only those systems that do fully understand the resources, and as a consequence implementers may believe that the narrative is superfluous. However experience shows that such eco-systems often open up to new participants over time." />
 102         </extension>
 103         <key value="dom-6" />
 104         <severity value="warning" />
 105         <human value="A resource should have narrative for robust management" />
 106         <expression value="text.`div`.exists()" />
 107         <xpath value="exists(f:text/h:div)" />
 108         <source value="http://hl7.org/fhir/StructureDefinition/DomainResource" />
 109       </constraint>
 110       <isModifier value="false" />
 111       <isSummary value="false" />
 112       <mapping>
 113         <identity value="rim" />
 114         <map value="Entity. Role, or Act" />
 115       </mapping>
 116     </element>
 117     <element id="SubstanceSpecification.id">
 118       <path value="SubstanceSpecification.id" />
 119       <short value="Logical id of this artifact" />
 120       <definition value="The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes." />
 121       <comment value="The only time that a resource does not have an id is when it is being submitted to the server using a create operation." />
 122       <min value="0" />
 123       <max value="1" />
 124       <base>
 125         <path value="Resource.id" />
 126         <min value="0" />
 127         <max value="1" />
 128       </base>
 129       <type>
 130         <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
 131           <valueUrl value="string" />
 132         </extension>
 133         <code value="http://hl7.org/fhirpath/System.String" />
 134       </type>
 135       <isModifier value="false" />
 136       <isSummary value="true" />
 137     </element>
 138     <element id="SubstanceSpecification.meta">
 139       <path value="SubstanceSpecification.meta" />
 140       <short value="Metadata about the resource" />
 141       <definition value="The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content might not always be associated with version changes to the resource." />
 142       <min value="0" />
 143       <max value="1" />
 144       <base>
 145         <path value="Resource.meta" />
 146         <min value="0" />
 147         <max value="1" />
 148       </base>
 149       <type>
 150         <code value="Meta" />
 151       </type>
 152       <constraint>
 153         <key value="ele-1" />
 154         <severity value="error" />
 155         <human value="All FHIR elements must have a @value or children" />
 156         <expression value="hasValue() or (children().count() > id.count())" />
 157         <xpath value="@value|f:*|h:div" />
 158         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 159       </constraint>
 160       <isModifier value="false" />
 161       <isSummary value="true" />
 162     </element>
 163     <element id="SubstanceSpecification.implicitRules">
 164       <path value="SubstanceSpecification.implicitRules" />
 165       <short value="A set of rules under which this content was created" />
 166       <definition value="A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc." />
 167       <comment value="Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of it's narrative along with other profiles, value sets, etc." />
 168       <min value="0" />
 169       <max value="1" />
 170       <base>
 171         <path value="Resource.implicitRules" />
 172         <min value="0" />
 173         <max value="1" />
 174       </base>
 175       <type>
 176         <code value="uri" />
 177       </type>
 178       <constraint>
 179         <key value="ele-1" />
 180         <severity value="error" />
 181         <human value="All FHIR elements must have a @value or children" />
 182         <expression value="hasValue() or (children().count() > id.count())" />
 183         <xpath value="@value|f:*|h:div" />
 184         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 185       </constraint>
 186       <isModifier value="true" />
 187       <isModifierReason value="This element is labeled as a modifier because the implicit rules may provide additional knowledge about the resource that modifies it's meaning or interpretation" />
 188       <isSummary value="true" />
 189     </element>
 190     <element id="SubstanceSpecification.language">
 191       <path value="SubstanceSpecification.language" />
 192       <short value="Language of the resource content" />
 193       <definition value="The base language in which the resource is written." />
 194       <comment value="Language is provided to support indexing and accessibility (typically, services such as text to speech use the language tag). The html language tag in the narrative applies  to the narrative. The language tag on the resource may be used to specify the language of other presentations generated from the data in the resource. Not all the content has to be in the base language. The Resource.language should not be assumed to apply to the narrative automatically. If a language is specified, it should it also be specified on the div element in the html (see rules in HTML5 for information about the relationship between xml:lang and the html lang attribute)." />
 195       <min value="0" />
 196       <max value="1" />
 197       <base>
 198         <path value="Resource.language" />
 199         <min value="0" />
 200         <max value="1" />
 201       </base>
 202       <type>
 203         <code value="code" />
 204       </type>
 205       <constraint>
 206         <key value="ele-1" />
 207         <severity value="error" />
 208         <human value="All FHIR elements must have a @value or children" />
 209         <expression value="hasValue() or (children().count() > id.count())" />
 210         <xpath value="@value|f:*|h:div" />
 211         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 212       </constraint>
 213       <isModifier value="false" />
 214       <isSummary value="false" />
 215       <binding>
 216         <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-maxValueSet">
 217           <valueCanonical value="http://hl7.org/fhir/ValueSet/all-languages" />
 218         </extension>
 219         <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
 220           <valueString value="Language" />
 221         </extension>
 222         <extension url="http://hl7.org/fhir/StructureDefinition/elementdefinition-isCommonBinding">
 223           <valueBoolean value="true" />
 224         </extension>
 225         <strength value="preferred" />
 226         <description value="A human language." />
 227         <valueSet value="http://hl7.org/fhir/ValueSet/languages" />
 228       </binding>
 229     </element>
 230     <element id="SubstanceSpecification.text">
 231       <path value="SubstanceSpecification.text" />
 232       <short value="Text summary of the resource, for human interpretation" />
 233       <definition value="A human-readable narrative that contains a summary of the resource and can be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it "clinically safe" for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety." />
 234       <comment value="Contained resources do not have narrative. Resources that are not contained SHOULD have a narrative. In some cases, a resource may only have text with little or no additional discrete data (as long as all minOccurs=1 elements are satisfied).  This may be necessary for data from legacy systems where information is captured as a "text blob" or where text is additionally entered raw or narrated and encoded information is added later." />
 235       <alias value="narrative" />
 236       <alias value="html" />
 237       <alias value="xhtml" />
 238       <alias value="display" />
 239       <min value="0" />
 240       <max value="1" />
 241       <base>
 242         <path value="DomainResource.text" />
 243         <min value="0" />
 244         <max value="1" />
 245       </base>
 246       <type>
 247         <code value="Narrative" />
 248       </type>
 249       <constraint>
 250         <key value="ele-1" />
 251         <severity value="error" />
 252         <human value="All FHIR elements must have a @value or children" />
 253         <expression value="hasValue() or (children().count() > id.count())" />
 254         <xpath value="@value|f:*|h:div" />
 255         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 256       </constraint>
 257       <isModifier value="false" />
 258       <isSummary value="false" />
 259       <mapping>
 260         <identity value="rim" />
 261         <map value="Act.text?" />
 262       </mapping>
 263     </element>
 264     <element id="SubstanceSpecification.contained">
 265       <path value="SubstanceSpecification.contained" />
 266       <short value="Contained, inline Resources" />
 267       <definition value="These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, and nor can they have their own independent transaction scope." />
 268       <comment value="This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again. Contained resources may have profiles and tags In their meta elements, but SHALL NOT have security labels." />
 269       <alias value="inline resources" />
 270       <alias value="anonymous resources" />
 271       <alias value="contained resources" />
 272       <min value="0" />
 273       <max value="*" />
 274       <base>
 275         <path value="DomainResource.contained" />
 276         <min value="0" />
 277         <max value="*" />
 278       </base>
 279       <type>
 280         <code value="Resource" />
 281       </type>
 282       <isModifier value="false" />
 283       <isSummary value="false" />
 284       <mapping>
 285         <identity value="rim" />
 286         <map value="N/A" />
 287       </mapping>
 288     </element>
 289     <element id="SubstanceSpecification.extension">
 290       <path value="SubstanceSpecification.extension" />
 291       <short value="Additional content defined by implementations" />
 292       <definition value="May be used to represent additional information that is not part of the basic definition of the resource. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." />
 293       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
 294       <alias value="extensions" />
 295       <alias value="user content" />
 296       <min value="0" />
 297       <max value="*" />
 298       <base>
 299         <path value="DomainResource.extension" />
 300         <min value="0" />
 301         <max value="*" />
 302       </base>
 303       <type>
 304         <code value="Extension" />
 305       </type>
 306       <constraint>
 307         <key value="ele-1" />
 308         <severity value="error" />
 309         <human value="All FHIR elements must have a @value or children" />
 310         <expression value="hasValue() or (children().count() > id.count())" />
 311         <xpath value="@value|f:*|h:div" />
 312         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 313       </constraint>
 314       <constraint>
 315         <key value="ext-1" />
 316         <severity value="error" />
 317         <human value="Must have either extensions or value[x], not both" />
 318         <expression value="extension.exists() != value.exists()" />
 319         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
 320         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
 321       </constraint>
 322       <isModifier value="false" />
 323       <isSummary value="false" />
 324       <mapping>
 325         <identity value="rim" />
 326         <map value="N/A" />
 327       </mapping>
 328     </element>
 329     <element id="SubstanceSpecification.modifierExtension">
 330       <path value="SubstanceSpecification.modifierExtension" />
 331       <short value="Extensions that cannot be ignored" />
 332       <definition value="May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)." />
 333       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
 334       <requirements value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](extensibility.html#modifierExtension)." />
 335       <alias value="extensions" />
 336       <alias value="user content" />
 337       <min value="0" />
 338       <max value="*" />
 339       <base>
 340         <path value="DomainResource.modifierExtension" />
 341         <min value="0" />
 342         <max value="*" />
 343       </base>
 344       <type>
 345         <code value="Extension" />
 346       </type>
 347       <constraint>
 348         <key value="ele-1" />
 349         <severity value="error" />
 350         <human value="All FHIR elements must have a @value or children" />
 351         <expression value="hasValue() or (children().count() > id.count())" />
 352         <xpath value="@value|f:*|h:div" />
 353         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 354       </constraint>
 355       <constraint>
 356         <key value="ext-1" />
 357         <severity value="error" />
 358         <human value="Must have either extensions or value[x], not both" />
 359         <expression value="extension.exists() != value.exists()" />
 360         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
 361         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
 362       </constraint>
 363       <isModifier value="true" />
 364       <isModifierReason value="Modifier extensions are expected to modify the meaning or interpretation of the resource that contains them" />
 365       <isSummary value="false" />
 366       <mapping>
 367         <identity value="rim" />
 368         <map value="N/A" />
 369       </mapping>
 370     </element>
 371     <element id="SubstanceSpecification.identifier">
 372       <path value="SubstanceSpecification.identifier" />
 373       <short value="Identifier by which this substance is known" />
 374       <definition value="Identifier by which this substance is known." />
 375       <min value="0" />
 376       <max value="1" />
 377       <base>
 378         <path value="SubstanceSpecification.identifier" />
 379         <min value="0" />
 380         <max value="1" />
 381       </base>
 382       <type>
 383         <code value="Identifier" />
 384       </type>
 385       <constraint>
 386         <key value="ele-1" />
 387         <severity value="error" />
 388         <human value="All FHIR elements must have a @value or children" />
 389         <expression value="hasValue() or (children().count() > id.count())" />
 390         <xpath value="@value|f:*|h:div" />
 391         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 392       </constraint>
 393       <isModifier value="false" />
 394       <isSummary value="true" />
 395     </element>
 396     <element id="SubstanceSpecification.type">
 397       <path value="SubstanceSpecification.type" />
 398       <short value="High level categorization, e.g. polymer or nucleic acid" />
 399       <definition value="High level categorization, e.g. polymer or nucleic acid." />
 400       <min value="0" />
 401       <max value="1" />
 402       <base>
 403         <path value="SubstanceSpecification.type" />
 404         <min value="0" />
 405         <max value="1" />
 406       </base>
 407       <type>
 408         <code value="CodeableConcept" />
 409       </type>
 410       <constraint>
 411         <key value="ele-1" />
 412         <severity value="error" />
 413         <human value="All FHIR elements must have a @value or children" />
 414         <expression value="hasValue() or (children().count() > id.count())" />
 415         <xpath value="@value|f:*|h:div" />
 416         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 417       </constraint>
 418       <isModifier value="false" />
 419       <isSummary value="true" />
 420     </element>
 421     <element id="SubstanceSpecification.status">
 422       <path value="SubstanceSpecification.status" />
 423       <short value="Status of substance within the catalogue e.g. approved" />
 424       <definition value="Status of substance within the catalogue e.g. approved." />
 425       <min value="0" />
 426       <max value="1" />
 427       <base>
 428         <path value="SubstanceSpecification.status" />
 429         <min value="0" />
 430         <max value="1" />
 431       </base>
 432       <type>
 433         <code value="CodeableConcept" />
 434       </type>
 435       <constraint>
 436         <key value="ele-1" />
 437         <severity value="error" />
 438         <human value="All FHIR elements must have a @value or children" />
 439         <expression value="hasValue() or (children().count() > id.count())" />
 440         <xpath value="@value|f:*|h:div" />
 441         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 442       </constraint>
 443       <isModifier value="false" />
 444       <isSummary value="true" />
 445     </element>
 446     <element id="SubstanceSpecification.domain">
 447       <path value="SubstanceSpecification.domain" />
 448       <short value="If the substance applies to only human or veterinary use" />
 449       <definition value="If the substance applies to only human or veterinary use." />
 450       <min value="0" />
 451       <max value="1" />
 452       <base>
 453         <path value="SubstanceSpecification.domain" />
 454         <min value="0" />
 455         <max value="1" />
 456       </base>
 457       <type>
 458         <code value="CodeableConcept" />
 459       </type>
 460       <constraint>
 461         <key value="ele-1" />
 462         <severity value="error" />
 463         <human value="All FHIR elements must have a @value or children" />
 464         <expression value="hasValue() or (children().count() > id.count())" />
 465         <xpath value="@value|f:*|h:div" />
 466         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 467       </constraint>
 468       <isModifier value="false" />
 469       <isSummary value="true" />
 470     </element>
 471     <element id="SubstanceSpecification.description">
 472       <path value="SubstanceSpecification.description" />
 473       <short value="Textual description of the substance" />
 474       <definition value="Textual description of the substance." />
 475       <min value="0" />
 476       <max value="1" />
 477       <base>
 478         <path value="SubstanceSpecification.description" />
 479         <min value="0" />
 480         <max value="1" />
 481       </base>
 482       <type>
 483         <code value="string" />
 484       </type>
 485       <constraint>
 486         <key value="ele-1" />
 487         <severity value="error" />
 488         <human value="All FHIR elements must have a @value or children" />
 489         <expression value="hasValue() or (children().count() > id.count())" />
 490         <xpath value="@value|f:*|h:div" />
 491         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 492       </constraint>
 493       <isModifier value="false" />
 494       <isSummary value="true" />
 495     </element>
 496     <element id="SubstanceSpecification.source">
 497       <path value="SubstanceSpecification.source" />
 498       <short value="Supporting literature" />
 499       <definition value="Supporting literature." />
 500       <min value="0" />
 501       <max value="*" />
 502       <base>
 503         <path value="SubstanceSpecification.source" />
 504         <min value="0" />
 505         <max value="*" />
 506       </base>
 507       <type>
 508         <code value="Reference" />
 509         <targetProfile value="http://hl7.org/fhir/StructureDefinition/DocumentReference" />
 510       </type>
 511       <constraint>
 512         <key value="ele-1" />
 513         <severity value="error" />
 514         <human value="All FHIR elements must have a @value or children" />
 515         <expression value="hasValue() or (children().count() > id.count())" />
 516         <xpath value="@value|f:*|h:div" />
 517         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 518       </constraint>
 519       <isModifier value="false" />
 520       <isSummary value="true" />
 521     </element>
 522     <element id="SubstanceSpecification.comment">
 523       <path value="SubstanceSpecification.comment" />
 524       <short value="Textual comment about this record of a substance" />
 525       <definition value="Textual comment about this record of a substance." />
 526       <min value="0" />
 527       <max value="1" />
 528       <base>
 529         <path value="SubstanceSpecification.comment" />
 530         <min value="0" />
 531         <max value="1" />
 532       </base>
 533       <type>
 534         <code value="string" />
 535       </type>
 536       <constraint>
 537         <key value="ele-1" />
 538         <severity value="error" />
 539         <human value="All FHIR elements must have a @value or children" />
 540         <expression value="hasValue() or (children().count() > id.count())" />
 541         <xpath value="@value|f:*|h:div" />
 542         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 543       </constraint>
 544       <isModifier value="false" />
 545       <isSummary value="true" />
 546     </element>
 547     <element id="SubstanceSpecification.moiety">
 548       <path value="SubstanceSpecification.moiety" />
 549       <short value="Moiety, for structural modifications" />
 550       <definition value="Moiety, for structural modifications." />
 551       <min value="0" />
 552       <max value="*" />
 553       <base>
 554         <path value="SubstanceSpecification.moiety" />
 555         <min value="0" />
 556         <max value="*" />
 557       </base>
 558       <type>
 559         <code value="BackboneElement" />
 560       </type>
 561       <constraint>
 562         <key value="ele-1" />
 563         <severity value="error" />
 564         <human value="All FHIR elements must have a @value or children" />
 565         <expression value="hasValue() or (children().count() > id.count())" />
 566         <xpath value="@value|f:*|h:div" />
 567         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 568       </constraint>
 569       <isModifier value="false" />
 570       <isSummary value="true" />
 571     </element>
 572     <element id="SubstanceSpecification.moiety.id">
 573       <path value="SubstanceSpecification.moiety.id" />
 574       <representation value="xmlAttr" />
 575       <short value="Unique id for inter-element referencing" />
 576       <definition value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." />
 577       <min value="0" />
 578       <max value="1" />
 579       <base>
 580         <path value="Element.id" />
 581         <min value="0" />
 582         <max value="1" />
 583       </base>
 584       <type>
 585         <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
 586           <valueUrl value="string" />
 587         </extension>
 588         <code value="http://hl7.org/fhirpath/System.String" />
 589       </type>
 590       <isModifier value="false" />
 591       <isSummary value="false" />
 592       <mapping>
 593         <identity value="rim" />
 594         <map value="n/a" />
 595       </mapping>
 596     </element>
 597     <element id="SubstanceSpecification.moiety.extension">
 598       <path value="SubstanceSpecification.moiety.extension" />
 599       <short value="Additional content defined by implementations" />
 600       <definition value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." />
 601       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
 602       <alias value="extensions" />
 603       <alias value="user content" />
 604       <min value="0" />
 605       <max value="*" />
 606       <base>
 607         <path value="Element.extension" />
 608         <min value="0" />
 609         <max value="*" />
 610       </base>
 611       <type>
 612         <code value="Extension" />
 613       </type>
 614       <constraint>
 615         <key value="ele-1" />
 616         <severity value="error" />
 617         <human value="All FHIR elements must have a @value or children" />
 618         <expression value="hasValue() or (children().count() > id.count())" />
 619         <xpath value="@value|f:*|h:div" />
 620         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 621       </constraint>
 622       <constraint>
 623         <key value="ext-1" />
 624         <severity value="error" />
 625         <human value="Must have either extensions or value[x], not both" />
 626         <expression value="extension.exists() != value.exists()" />
 627         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
 628         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
 629       </constraint>
 630       <isModifier value="false" />
 631       <isSummary value="false" />
 632       <mapping>
 633         <identity value="rim" />
 634         <map value="n/a" />
 635       </mapping>
 636     </element>
 637     <element id="SubstanceSpecification.moiety.modifierExtension">
 638       <path value="SubstanceSpecification.moiety.modifierExtension" />
 639       <short value="Extensions that cannot be ignored even if unrecognized" />
 640       <definition value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)." />
 641       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
 642       <requirements value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](extensibility.html#modifierExtension)." />
 643       <alias value="extensions" />
 644       <alias value="user content" />
 645       <alias value="modifiers" />
 646       <min value="0" />
 647       <max value="*" />
 648       <base>
 649         <path value="BackboneElement.modifierExtension" />
 650         <min value="0" />
 651         <max value="*" />
 652       </base>
 653       <type>
 654         <code value="Extension" />
 655       </type>
 656       <constraint>
 657         <key value="ele-1" />
 658         <severity value="error" />
 659         <human value="All FHIR elements must have a @value or children" />
 660         <expression value="hasValue() or (children().count() > id.count())" />
 661         <xpath value="@value|f:*|h:div" />
 662         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 663       </constraint>
 664       <constraint>
 665         <key value="ext-1" />
 666         <severity value="error" />
 667         <human value="Must have either extensions or value[x], not both" />
 668         <expression value="extension.exists() != value.exists()" />
 669         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
 670         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
 671       </constraint>
 672       <isModifier value="true" />
 673       <isModifierReason value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them" />
 674       <isSummary value="true" />
 675       <mapping>
 676         <identity value="rim" />
 677         <map value="N/A" />
 678       </mapping>
 679     </element>
 680     <element id="SubstanceSpecification.moiety.role">
 681       <path value="SubstanceSpecification.moiety.role" />
 682       <short value="Role that the moiety is playing" />
 683       <definition value="Role that the moiety is playing." />
 684       <min value="0" />
 685       <max value="1" />
 686       <base>
 687         <path value="SubstanceSpecification.moiety.role" />
 688         <min value="0" />
 689         <max value="1" />
 690       </base>
 691       <type>
 692         <code value="CodeableConcept" />
 693       </type>
 694       <constraint>
 695         <key value="ele-1" />
 696         <severity value="error" />
 697         <human value="All FHIR elements must have a @value or children" />
 698         <expression value="hasValue() or (children().count() > id.count())" />
 699         <xpath value="@value|f:*|h:div" />
 700         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 701       </constraint>
 702       <isModifier value="false" />
 703       <isSummary value="true" />
 704     </element>
 705     <element id="SubstanceSpecification.moiety.identifier">
 706       <path value="SubstanceSpecification.moiety.identifier" />
 707       <short value="Identifier by which this moiety substance is known" />
 708       <definition value="Identifier by which this moiety substance is known." />
 709       <min value="0" />
 710       <max value="1" />
 711       <base>
 712         <path value="SubstanceSpecification.moiety.identifier" />
 713         <min value="0" />
 714         <max value="1" />
 715       </base>
 716       <type>
 717         <code value="Identifier" />
 718       </type>
 719       <constraint>
 720         <key value="ele-1" />
 721         <severity value="error" />
 722         <human value="All FHIR elements must have a @value or children" />
 723         <expression value="hasValue() or (children().count() > id.count())" />
 724         <xpath value="@value|f:*|h:div" />
 725         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 726       </constraint>
 727       <isModifier value="false" />
 728       <isSummary value="true" />
 729     </element>
 730     <element id="SubstanceSpecification.moiety.name">
 731       <path value="SubstanceSpecification.moiety.name" />
 732       <short value="Textual name for this moiety substance" />
 733       <definition value="Textual name for this moiety substance." />
 734       <min value="0" />
 735       <max value="1" />
 736       <base>
 737         <path value="SubstanceSpecification.moiety.name" />
 738         <min value="0" />
 739         <max value="1" />
 740       </base>
 741       <type>
 742         <code value="string" />
 743       </type>
 744       <constraint>
 745         <key value="ele-1" />
 746         <severity value="error" />
 747         <human value="All FHIR elements must have a @value or children" />
 748         <expression value="hasValue() or (children().count() > id.count())" />
 749         <xpath value="@value|f:*|h:div" />
 750         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 751       </constraint>
 752       <isModifier value="false" />
 753       <isSummary value="true" />
 754     </element>
 755     <element id="SubstanceSpecification.moiety.stereochemistry">
 756       <path value="SubstanceSpecification.moiety.stereochemistry" />
 757       <short value="Stereochemistry type" />
 758       <definition value="Stereochemistry type." />
 759       <min value="0" />
 760       <max value="1" />
 761       <base>
 762         <path value="SubstanceSpecification.moiety.stereochemistry" />
 763         <min value="0" />
 764         <max value="1" />
 765       </base>
 766       <type>
 767         <code value="CodeableConcept" />
 768       </type>
 769       <constraint>
 770         <key value="ele-1" />
 771         <severity value="error" />
 772         <human value="All FHIR elements must have a @value or children" />
 773         <expression value="hasValue() or (children().count() > id.count())" />
 774         <xpath value="@value|f:*|h:div" />
 775         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 776       </constraint>
 777       <isModifier value="false" />
 778       <isSummary value="true" />
 779     </element>
 780     <element id="SubstanceSpecification.moiety.opticalActivity">
 781       <path value="SubstanceSpecification.moiety.opticalActivity" />
 782       <short value="Optical activity type" />
 783       <definition value="Optical activity type." />
 784       <min value="0" />
 785       <max value="1" />
 786       <base>
 787         <path value="SubstanceSpecification.moiety.opticalActivity" />
 788         <min value="0" />
 789         <max value="1" />
 790       </base>
 791       <type>
 792         <code value="CodeableConcept" />
 793       </type>
 794       <constraint>
 795         <key value="ele-1" />
 796         <severity value="error" />
 797         <human value="All FHIR elements must have a @value or children" />
 798         <expression value="hasValue() or (children().count() > id.count())" />
 799         <xpath value="@value|f:*|h:div" />
 800         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 801       </constraint>
 802       <isModifier value="false" />
 803       <isSummary value="true" />
 804     </element>
 805     <element id="SubstanceSpecification.moiety.molecularFormula">
 806       <path value="SubstanceSpecification.moiety.molecularFormula" />
 807       <short value="Molecular formula" />
 808       <definition value="Molecular formula." />
 809       <min value="0" />
 810       <max value="1" />
 811       <base>
 812         <path value="SubstanceSpecification.moiety.molecularFormula" />
 813         <min value="0" />
 814         <max value="1" />
 815       </base>
 816       <type>
 817         <code value="string" />
 818       </type>
 819       <constraint>
 820         <key value="ele-1" />
 821         <severity value="error" />
 822         <human value="All FHIR elements must have a @value or children" />
 823         <expression value="hasValue() or (children().count() > id.count())" />
 824         <xpath value="@value|f:*|h:div" />
 825         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 826       </constraint>
 827       <isModifier value="false" />
 828       <isSummary value="true" />
 829     </element>
 830     <element id="SubstanceSpecification.moiety.amount[x]">
 831       <path value="SubstanceSpecification.moiety.amount[x]" />
 832       <short value="Quantitative value for this moiety" />
 833       <definition value="Quantitative value for this moiety." />
 834       <min value="0" />
 835       <max value="1" />
 836       <base>
 837         <path value="SubstanceSpecification.moiety.amount[x]" />
 838         <min value="0" />
 839         <max value="1" />
 840       </base>
 841       <type>
 842         <code value="Quantity" />
 843       </type>
 844       <type>
 845         <code value="string" />
 846       </type>
 847       <constraint>
 848         <key value="ele-1" />
 849         <severity value="error" />
 850         <human value="All FHIR elements must have a @value or children" />
 851         <expression value="hasValue() or (children().count() > id.count())" />
 852         <xpath value="@value|f:*|h:div" />
 853         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 854       </constraint>
 855       <isModifier value="false" />
 856       <isSummary value="true" />
 857     </element>
 858     <element id="SubstanceSpecification.property">
 859       <path value="SubstanceSpecification.property" />
 860       <short value="General specifications for this substance, including how it is related to other substances" />
 861       <definition value="General specifications for this substance, including how it is related to other substances." />
 862       <min value="0" />
 863       <max value="*" />
 864       <base>
 865         <path value="SubstanceSpecification.property" />
 866         <min value="0" />
 867         <max value="*" />
 868       </base>
 869       <type>
 870         <code value="BackboneElement" />
 871       </type>
 872       <constraint>
 873         <key value="ele-1" />
 874         <severity value="error" />
 875         <human value="All FHIR elements must have a @value or children" />
 876         <expression value="hasValue() or (children().count() > id.count())" />
 877         <xpath value="@value|f:*|h:div" />
 878         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 879       </constraint>
 880       <isModifier value="false" />
 881       <isSummary value="true" />
 882     </element>
 883     <element id="SubstanceSpecification.property.id">
 884       <path value="SubstanceSpecification.property.id" />
 885       <representation value="xmlAttr" />
 886       <short value="Unique id for inter-element referencing" />
 887       <definition value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." />
 888       <min value="0" />
 889       <max value="1" />
 890       <base>
 891         <path value="Element.id" />
 892         <min value="0" />
 893         <max value="1" />
 894       </base>
 895       <type>
 896         <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
 897           <valueUrl value="string" />
 898         </extension>
 899         <code value="http://hl7.org/fhirpath/System.String" />
 900       </type>
 901       <isModifier value="false" />
 902       <isSummary value="false" />
 903       <mapping>
 904         <identity value="rim" />
 905         <map value="n/a" />
 906       </mapping>
 907     </element>
 908     <element id="SubstanceSpecification.property.extension">
 909       <path value="SubstanceSpecification.property.extension" />
 910       <short value="Additional content defined by implementations" />
 911       <definition value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." />
 912       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
 913       <alias value="extensions" />
 914       <alias value="user content" />
 915       <min value="0" />
 916       <max value="*" />
 917       <base>
 918         <path value="Element.extension" />
 919         <min value="0" />
 920         <max value="*" />
 921       </base>
 922       <type>
 923         <code value="Extension" />
 924       </type>
 925       <constraint>
 926         <key value="ele-1" />
 927         <severity value="error" />
 928         <human value="All FHIR elements must have a @value or children" />
 929         <expression value="hasValue() or (children().count() > id.count())" />
 930         <xpath value="@value|f:*|h:div" />
 931         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 932       </constraint>
 933       <constraint>
 934         <key value="ext-1" />
 935         <severity value="error" />
 936         <human value="Must have either extensions or value[x], not both" />
 937         <expression value="extension.exists() != value.exists()" />
 938         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
 939         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
 940       </constraint>
 941       <isModifier value="false" />
 942       <isSummary value="false" />
 943       <mapping>
 944         <identity value="rim" />
 945         <map value="n/a" />
 946       </mapping>
 947     </element>
 948     <element id="SubstanceSpecification.property.modifierExtension">
 949       <path value="SubstanceSpecification.property.modifierExtension" />
 950       <short value="Extensions that cannot be ignored even if unrecognized" />
 951       <definition value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)." />
 952       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
 953       <requirements value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](extensibility.html#modifierExtension)." />
 954       <alias value="extensions" />
 955       <alias value="user content" />
 956       <alias value="modifiers" />
 957       <min value="0" />
 958       <max value="*" />
 959       <base>
 960         <path value="BackboneElement.modifierExtension" />
 961         <min value="0" />
 962         <max value="*" />
 963       </base>
 964       <type>
 965         <code value="Extension" />
 966       </type>
 967       <constraint>
 968         <key value="ele-1" />
 969         <severity value="error" />
 970         <human value="All FHIR elements must have a @value or children" />
 971         <expression value="hasValue() or (children().count() > id.count())" />
 972         <xpath value="@value|f:*|h:div" />
 973         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
 974       </constraint>
 975       <constraint>
 976         <key value="ext-1" />
 977         <severity value="error" />
 978         <human value="Must have either extensions or value[x], not both" />
 979         <expression value="extension.exists() != value.exists()" />
 980         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
 981         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
 982       </constraint>
 983       <isModifier value="true" />
 984       <isModifierReason value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them" />
 985       <isSummary value="true" />
 986       <mapping>
 987         <identity value="rim" />
 988         <map value="N/A" />
 989       </mapping>
 990     </element>
 991     <element id="SubstanceSpecification.property.category">
 992       <path value="SubstanceSpecification.property.category" />
 993       <short value="A category for this property, e.g. Physical, Chemical, Enzymatic" />
 994       <definition value="A category for this property, e.g. Physical, Chemical, Enzymatic." />
 995       <min value="0" />
 996       <max value="1" />
 997       <base>
 998         <path value="SubstanceSpecification.property.category" />
 999         <min value="0" />
1000         <max value="1" />
1001       </base>
1002       <type>
1003         <code value="CodeableConcept" />
1004       </type>
1005       <constraint>
1006         <key value="ele-1" />
1007         <severity value="error" />
1008         <human value="All FHIR elements must have a @value or children" />
1009         <expression value="hasValue() or (children().count() > id.count())" />
1010         <xpath value="@value|f:*|h:div" />
1011         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1012       </constraint>
1013       <isModifier value="false" />
1014       <isSummary value="true" />
1015     </element>
1016     <element id="SubstanceSpecification.property.code">
1017       <path value="SubstanceSpecification.property.code" />
1018       <short value="Property type e.g. viscosity, pH, isoelectric point" />
1019       <definition value="Property type e.g. viscosity, pH, isoelectric point." />
1020       <min value="0" />
1021       <max value="1" />
1022       <base>
1023         <path value="SubstanceSpecification.property.code" />
1024         <min value="0" />
1025         <max value="1" />
1026       </base>
1027       <type>
1028         <code value="CodeableConcept" />
1029       </type>
1030       <constraint>
1031         <key value="ele-1" />
1032         <severity value="error" />
1033         <human value="All FHIR elements must have a @value or children" />
1034         <expression value="hasValue() or (children().count() > id.count())" />
1035         <xpath value="@value|f:*|h:div" />
1036         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1037       </constraint>
1038       <isModifier value="false" />
1039       <isSummary value="true" />
1040     </element>
1041     <element id="SubstanceSpecification.property.parameters">
1042       <path value="SubstanceSpecification.property.parameters" />
1043       <short value="Parameters that were used in the measurement of a property (e.g. for viscosity: measured at 20C with a pH of 7.1)" />
1044       <definition value="Parameters that were used in the measurement of a property (e.g. for viscosity: measured at 20C with a pH of 7.1)." />
1045       <min value="0" />
1046       <max value="1" />
1047       <base>
1048         <path value="SubstanceSpecification.property.parameters" />
1049         <min value="0" />
1050         <max value="1" />
1051       </base>
1052       <type>
1053         <code value="string" />
1054       </type>
1055       <constraint>
1056         <key value="ele-1" />
1057         <severity value="error" />
1058         <human value="All FHIR elements must have a @value or children" />
1059         <expression value="hasValue() or (children().count() > id.count())" />
1060         <xpath value="@value|f:*|h:div" />
1061         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1062       </constraint>
1063       <isModifier value="false" />
1064       <isSummary value="true" />
1065     </element>
1066     <element id="SubstanceSpecification.property.definingSubstance[x]">
1067       <path value="SubstanceSpecification.property.definingSubstance[x]" />
1068       <short value="A substance upon which a defining property depends (e.g. for solubility: in water, in alcohol)" />
1069       <definition value="A substance upon which a defining property depends (e.g. for solubility: in water, in alcohol)." />
1070       <min value="0" />
1071       <max value="1" />
1072       <base>
1073         <path value="SubstanceSpecification.property.definingSubstance[x]" />
1074         <min value="0" />
1075         <max value="1" />
1076       </base>
1077       <type>
1078         <code value="Reference" />
1079         <targetProfile value="http://hl7.org/fhir/StructureDefinition/SubstanceSpecification" />
1080         <targetProfile value="http://hl7.org/fhir/StructureDefinition/Substance" />
1081       </type>
1082       <type>
1083         <code value="CodeableConcept" />
1084       </type>
1085       <constraint>
1086         <key value="ele-1" />
1087         <severity value="error" />
1088         <human value="All FHIR elements must have a @value or children" />
1089         <expression value="hasValue() or (children().count() > id.count())" />
1090         <xpath value="@value|f:*|h:div" />
1091         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1092       </constraint>
1093       <isModifier value="false" />
1094       <isSummary value="true" />
1095     </element>
1096     <element id="SubstanceSpecification.property.amount[x]">
1097       <path value="SubstanceSpecification.property.amount[x]" />
1098       <short value="Quantitative value for this property" />
1099       <definition value="Quantitative value for this property." />
1100       <min value="0" />
1101       <max value="1" />
1102       <base>
1103         <path value="SubstanceSpecification.property.amount[x]" />
1104         <min value="0" />
1105         <max value="1" />
1106       </base>
1107       <type>
1108         <code value="Quantity" />
1109       </type>
1110       <type>
1111         <code value="string" />
1112       </type>
1113       <constraint>
1114         <key value="ele-1" />
1115         <severity value="error" />
1116         <human value="All FHIR elements must have a @value or children" />
1117         <expression value="hasValue() or (children().count() > id.count())" />
1118         <xpath value="@value|f:*|h:div" />
1119         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1120       </constraint>
1121       <isModifier value="false" />
1122       <isSummary value="true" />
1123     </element>
1124     <element id="SubstanceSpecification.referenceInformation">
1125       <path value="SubstanceSpecification.referenceInformation" />
1126       <short value="General information detailing this substance" />
1127       <definition value="General information detailing this substance." />
1128       <min value="0" />
1129       <max value="1" />
1130       <base>
1131         <path value="SubstanceSpecification.referenceInformation" />
1132         <min value="0" />
1133         <max value="1" />
1134       </base>
1135       <type>
1136         <code value="Reference" />
1137         <targetProfile value="http://hl7.org/fhir/StructureDefinition/SubstanceReferenceInformation" />
1138       </type>
1139       <constraint>
1140         <key value="ele-1" />
1141         <severity value="error" />
1142         <human value="All FHIR elements must have a @value or children" />
1143         <expression value="hasValue() or (children().count() > id.count())" />
1144         <xpath value="@value|f:*|h:div" />
1145         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1146       </constraint>
1147       <isModifier value="false" />
1148       <isSummary value="true" />
1149     </element>
1150     <element id="SubstanceSpecification.structure">
1151       <path value="SubstanceSpecification.structure" />
1152       <short value="Structural information" />
1153       <definition value="Structural information." />
1154       <min value="0" />
1155       <max value="1" />
1156       <base>
1157         <path value="SubstanceSpecification.structure" />
1158         <min value="0" />
1159         <max value="1" />
1160       </base>
1161       <type>
1162         <code value="BackboneElement" />
1163       </type>
1164       <constraint>
1165         <key value="ele-1" />
1166         <severity value="error" />
1167         <human value="All FHIR elements must have a @value or children" />
1168         <expression value="hasValue() or (children().count() > id.count())" />
1169         <xpath value="@value|f:*|h:div" />
1170         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1171       </constraint>
1172       <isModifier value="false" />
1173       <isSummary value="true" />
1174     </element>
1175     <element id="SubstanceSpecification.structure.id">
1176       <path value="SubstanceSpecification.structure.id" />
1177       <representation value="xmlAttr" />
1178       <short value="Unique id for inter-element referencing" />
1179       <definition value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." />
1180       <min value="0" />
1181       <max value="1" />
1182       <base>
1183         <path value="Element.id" />
1184         <min value="0" />
1185         <max value="1" />
1186       </base>
1187       <type>
1188         <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
1189           <valueUrl value="string" />
1190         </extension>
1191         <code value="http://hl7.org/fhirpath/System.String" />
1192       </type>
1193       <isModifier value="false" />
1194       <isSummary value="false" />
1195       <mapping>
1196         <identity value="rim" />
1197         <map value="n/a" />
1198       </mapping>
1199     </element>
1200     <element id="SubstanceSpecification.structure.extension">
1201       <path value="SubstanceSpecification.structure.extension" />
1202       <short value="Additional content defined by implementations" />
1203       <definition value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." />
1204       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
1205       <alias value="extensions" />
1206       <alias value="user content" />
1207       <min value="0" />
1208       <max value="*" />
1209       <base>
1210         <path value="Element.extension" />
1211         <min value="0" />
1212         <max value="*" />
1213       </base>
1214       <type>
1215         <code value="Extension" />
1216       </type>
1217       <constraint>
1218         <key value="ele-1" />
1219         <severity value="error" />
1220         <human value="All FHIR elements must have a @value or children" />
1221         <expression value="hasValue() or (children().count() > id.count())" />
1222         <xpath value="@value|f:*|h:div" />
1223         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1224       </constraint>
1225       <constraint>
1226         <key value="ext-1" />
1227         <severity value="error" />
1228         <human value="Must have either extensions or value[x], not both" />
1229         <expression value="extension.exists() != value.exists()" />
1230         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
1231         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
1232       </constraint>
1233       <isModifier value="false" />
1234       <isSummary value="false" />
1235       <mapping>
1236         <identity value="rim" />
1237         <map value="n/a" />
1238       </mapping>
1239     </element>
1240     <element id="SubstanceSpecification.structure.modifierExtension">
1241       <path value="SubstanceSpecification.structure.modifierExtension" />
1242       <short value="Extensions that cannot be ignored even if unrecognized" />
1243       <definition value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)." />
1244       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
1245       <requirements value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](extensibility.html#modifierExtension)." />
1246       <alias value="extensions" />
1247       <alias value="user content" />
1248       <alias value="modifiers" />
1249       <min value="0" />
1250       <max value="*" />
1251       <base>
1252         <path value="BackboneElement.modifierExtension" />
1253         <min value="0" />
1254         <max value="*" />
1255       </base>
1256       <type>
1257         <code value="Extension" />
1258       </type>
1259       <constraint>
1260         <key value="ele-1" />
1261         <severity value="error" />
1262         <human value="All FHIR elements must have a @value or children" />
1263         <expression value="hasValue() or (children().count() > id.count())" />
1264         <xpath value="@value|f:*|h:div" />
1265         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1266       </constraint>
1267       <constraint>
1268         <key value="ext-1" />
1269         <severity value="error" />
1270         <human value="Must have either extensions or value[x], not both" />
1271         <expression value="extension.exists() != value.exists()" />
1272         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
1273         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
1274       </constraint>
1275       <isModifier value="true" />
1276       <isModifierReason value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them" />
1277       <isSummary value="true" />
1278       <mapping>
1279         <identity value="rim" />
1280         <map value="N/A" />
1281       </mapping>
1282     </element>
1283     <element id="SubstanceSpecification.structure.stereochemistry">
1284       <path value="SubstanceSpecification.structure.stereochemistry" />
1285       <short value="Stereochemistry type" />
1286       <definition value="Stereochemistry type." />
1287       <min value="0" />
1288       <max value="1" />
1289       <base>
1290         <path value="SubstanceSpecification.structure.stereochemistry" />
1291         <min value="0" />
1292         <max value="1" />
1293       </base>
1294       <type>
1295         <code value="CodeableConcept" />
1296       </type>
1297       <constraint>
1298         <key value="ele-1" />
1299         <severity value="error" />
1300         <human value="All FHIR elements must have a @value or children" />
1301         <expression value="hasValue() or (children().count() > id.count())" />
1302         <xpath value="@value|f:*|h:div" />
1303         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1304       </constraint>
1305       <isModifier value="false" />
1306       <isSummary value="true" />
1307     </element>
1308     <element id="SubstanceSpecification.structure.opticalActivity">
1309       <path value="SubstanceSpecification.structure.opticalActivity" />
1310       <short value="Optical activity type" />
1311       <definition value="Optical activity type." />
1312       <min value="0" />
1313       <max value="1" />
1314       <base>
1315         <path value="SubstanceSpecification.structure.opticalActivity" />
1316         <min value="0" />
1317         <max value="1" />
1318       </base>
1319       <type>
1320         <code value="CodeableConcept" />
1321       </type>
1322       <constraint>
1323         <key value="ele-1" />
1324         <severity value="error" />
1325         <human value="All FHIR elements must have a @value or children" />
1326         <expression value="hasValue() or (children().count() > id.count())" />
1327         <xpath value="@value|f:*|h:div" />
1328         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1329       </constraint>
1330       <isModifier value="false" />
1331       <isSummary value="true" />
1332     </element>
1333     <element id="SubstanceSpecification.structure.molecularFormula">
1334       <path value="SubstanceSpecification.structure.molecularFormula" />
1335       <short value="Molecular formula" />
1336       <definition value="Molecular formula." />
1337       <min value="0" />
1338       <max value="1" />
1339       <base>
1340         <path value="SubstanceSpecification.structure.molecularFormula" />
1341         <min value="0" />
1342         <max value="1" />
1343       </base>
1344       <type>
1345         <code value="string" />
1346       </type>
1347       <constraint>
1348         <key value="ele-1" />
1349         <severity value="error" />
1350         <human value="All FHIR elements must have a @value or children" />
1351         <expression value="hasValue() or (children().count() > id.count())" />
1352         <xpath value="@value|f:*|h:div" />
1353         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1354       </constraint>
1355       <isModifier value="false" />
1356       <isSummary value="true" />
1357     </element>
1358     <element id="SubstanceSpecification.structure.molecularFormulaByMoiety">
1359       <path value="SubstanceSpecification.structure.molecularFormulaByMoiety" />
1360       <short value="Specified per moiety according to the Hill system, i.e. first C, then H, then alphabetical, each moiety separated by a dot" />
1361       <definition value="Specified per moiety according to the Hill system, i.e. first C, then H, then alphabetical, each moiety separated by a dot." />
1362       <min value="0" />
1363       <max value="1" />
1364       <base>
1365         <path value="SubstanceSpecification.structure.molecularFormulaByMoiety" />
1366         <min value="0" />
1367         <max value="1" />
1368       </base>
1369       <type>
1370         <code value="string" />
1371       </type>
1372       <constraint>
1373         <key value="ele-1" />
1374         <severity value="error" />
1375         <human value="All FHIR elements must have a @value or children" />
1376         <expression value="hasValue() or (children().count() > id.count())" />
1377         <xpath value="@value|f:*|h:div" />
1378         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1379       </constraint>
1380       <isModifier value="false" />
1381       <isSummary value="true" />
1382     </element>
1383     <element id="SubstanceSpecification.structure.isotope">
1384       <path value="SubstanceSpecification.structure.isotope" />
1385       <short value="Applicable for single substances that contain a radionuclide or a non-natural isotopic ratio" />
1386       <definition value="Applicable for single substances that contain a radionuclide or a non-natural isotopic ratio." />
1387       <min value="0" />
1388       <max value="*" />
1389       <base>
1390         <path value="SubstanceSpecification.structure.isotope" />
1391         <min value="0" />
1392         <max value="*" />
1393       </base>
1394       <type>
1395         <code value="BackboneElement" />
1396       </type>
1397       <constraint>
1398         <key value="ele-1" />
1399         <severity value="error" />
1400         <human value="All FHIR elements must have a @value or children" />
1401         <expression value="hasValue() or (children().count() > id.count())" />
1402         <xpath value="@value|f:*|h:div" />
1403         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1404       </constraint>
1405       <isModifier value="false" />
1406       <isSummary value="true" />
1407     </element>
1408     <element id="SubstanceSpecification.structure.isotope.id">
1409       <path value="SubstanceSpecification.structure.isotope.id" />
1410       <representation value="xmlAttr" />
1411       <short value="Unique id for inter-element referencing" />
1412       <definition value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." />
1413       <min value="0" />
1414       <max value="1" />
1415       <base>
1416         <path value="Element.id" />
1417         <min value="0" />
1418         <max value="1" />
1419       </base>
1420       <type>
1421         <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
1422           <valueUrl value="string" />
1423         </extension>
1424         <code value="http://hl7.org/fhirpath/System.String" />
1425       </type>
1426       <isModifier value="false" />
1427       <isSummary value="false" />
1428       <mapping>
1429         <identity value="rim" />
1430         <map value="n/a" />
1431       </mapping>
1432     </element>
1433     <element id="SubstanceSpecification.structure.isotope.extension">
1434       <path value="SubstanceSpecification.structure.isotope.extension" />
1435       <short value="Additional content defined by implementations" />
1436       <definition value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." />
1437       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
1438       <alias value="extensions" />
1439       <alias value="user content" />
1440       <min value="0" />
1441       <max value="*" />
1442       <base>
1443         <path value="Element.extension" />
1444         <min value="0" />
1445         <max value="*" />
1446       </base>
1447       <type>
1448         <code value="Extension" />
1449       </type>
1450       <constraint>
1451         <key value="ele-1" />
1452         <severity value="error" />
1453         <human value="All FHIR elements must have a @value or children" />
1454         <expression value="hasValue() or (children().count() > id.count())" />
1455         <xpath value="@value|f:*|h:div" />
1456         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1457       </constraint>
1458       <constraint>
1459         <key value="ext-1" />
1460         <severity value="error" />
1461         <human value="Must have either extensions or value[x], not both" />
1462         <expression value="extension.exists() != value.exists()" />
1463         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
1464         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
1465       </constraint>
1466       <isModifier value="false" />
1467       <isSummary value="false" />
1468       <mapping>
1469         <identity value="rim" />
1470         <map value="n/a" />
1471       </mapping>
1472     </element>
1473     <element id="SubstanceSpecification.structure.isotope.modifierExtension">
1474       <path value="SubstanceSpecification.structure.isotope.modifierExtension" />
1475       <short value="Extensions that cannot be ignored even if unrecognized" />
1476       <definition value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)." />
1477       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
1478       <requirements value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](extensibility.html#modifierExtension)." />
1479       <alias value="extensions" />
1480       <alias value="user content" />
1481       <alias value="modifiers" />
1482       <min value="0" />
1483       <max value="*" />
1484       <base>
1485         <path value="BackboneElement.modifierExtension" />
1486         <min value="0" />
1487         <max value="*" />
1488       </base>
1489       <type>
1490         <code value="Extension" />
1491       </type>
1492       <constraint>
1493         <key value="ele-1" />
1494         <severity value="error" />
1495         <human value="All FHIR elements must have a @value or children" />
1496         <expression value="hasValue() or (children().count() > id.count())" />
1497         <xpath value="@value|f:*|h:div" />
1498         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1499       </constraint>
1500       <constraint>
1501         <key value="ext-1" />
1502         <severity value="error" />
1503         <human value="Must have either extensions or value[x], not both" />
1504         <expression value="extension.exists() != value.exists()" />
1505         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
1506         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
1507       </constraint>
1508       <isModifier value="true" />
1509       <isModifierReason value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them" />
1510       <isSummary value="true" />
1511       <mapping>
1512         <identity value="rim" />
1513         <map value="N/A" />
1514       </mapping>
1515     </element>
1516     <element id="SubstanceSpecification.structure.isotope.identifier">
1517       <path value="SubstanceSpecification.structure.isotope.identifier" />
1518       <short value="Substance identifier for each non-natural or radioisotope" />
1519       <definition value="Substance identifier for each non-natural or radioisotope." />
1520       <min value="0" />
1521       <max value="1" />
1522       <base>
1523         <path value="SubstanceSpecification.structure.isotope.identifier" />
1524         <min value="0" />
1525         <max value="1" />
1526       </base>
1527       <type>
1528         <code value="Identifier" />
1529       </type>
1530       <constraint>
1531         <key value="ele-1" />
1532         <severity value="error" />
1533         <human value="All FHIR elements must have a @value or children" />
1534         <expression value="hasValue() or (children().count() > id.count())" />
1535         <xpath value="@value|f:*|h:div" />
1536         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1537       </constraint>
1538       <isModifier value="false" />
1539       <isSummary value="true" />
1540     </element>
1541     <element id="SubstanceSpecification.structure.isotope.name">
1542       <path value="SubstanceSpecification.structure.isotope.name" />
1543       <short value="Substance name for each non-natural or radioisotope" />
1544       <definition value="Substance name for each non-natural or radioisotope." />
1545       <min value="0" />
1546       <max value="1" />
1547       <base>
1548         <path value="SubstanceSpecification.structure.isotope.name" />
1549         <min value="0" />
1550         <max value="1" />
1551       </base>
1552       <type>
1553         <code value="CodeableConcept" />
1554       </type>
1555       <constraint>
1556         <key value="ele-1" />
1557         <severity value="error" />
1558         <human value="All FHIR elements must have a @value or children" />
1559         <expression value="hasValue() or (children().count() > id.count())" />
1560         <xpath value="@value|f:*|h:div" />
1561         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1562       </constraint>
1563       <isModifier value="false" />
1564       <isSummary value="true" />
1565     </element>
1566     <element id="SubstanceSpecification.structure.isotope.substitution">
1567       <path value="SubstanceSpecification.structure.isotope.substitution" />
1568       <short value="The type of isotopic substitution present in a single substance" />
1569       <definition value="The type of isotopic substitution present in a single substance." />
1570       <min value="0" />
1571       <max value="1" />
1572       <base>
1573         <path value="SubstanceSpecification.structure.isotope.substitution" />
1574         <min value="0" />
1575         <max value="1" />
1576       </base>
1577       <type>
1578         <code value="CodeableConcept" />
1579       </type>
1580       <constraint>
1581         <key value="ele-1" />
1582         <severity value="error" />
1583         <human value="All FHIR elements must have a @value or children" />
1584         <expression value="hasValue() or (children().count() > id.count())" />
1585         <xpath value="@value|f:*|h:div" />
1586         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1587       </constraint>
1588       <isModifier value="false" />
1589       <isSummary value="true" />
1590     </element>
1591     <element id="SubstanceSpecification.structure.isotope.halfLife">
1592       <path value="SubstanceSpecification.structure.isotope.halfLife" />
1593       <short value="Half life - for a non-natural nuclide" />
1594       <definition value="Half life - for a non-natural nuclide." />
1595       <min value="0" />
1596       <max value="1" />
1597       <base>
1598         <path value="SubstanceSpecification.structure.isotope.halfLife" />
1599         <min value="0" />
1600         <max value="1" />
1601       </base>
1602       <type>
1603         <code value="Quantity" />
1604       </type>
1605       <constraint>
1606         <key value="ele-1" />
1607         <severity value="error" />
1608         <human value="All FHIR elements must have a @value or children" />
1609         <expression value="hasValue() or (children().count() > id.count())" />
1610         <xpath value="@value|f:*|h:div" />
1611         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1612       </constraint>
1613       <isModifier value="false" />
1614       <isSummary value="true" />
1615     </element>
1616     <element id="SubstanceSpecification.structure.isotope.molecularWeight">
1617       <path value="SubstanceSpecification.structure.isotope.molecularWeight" />
1618       <short value="The molecular weight or weight range (for proteins, polymers or nucleic acids)" />
1619       <definition value="The molecular weight or weight range (for proteins, polymers or nucleic acids)." />
1620       <min value="0" />
1621       <max value="1" />
1622       <base>
1623         <path value="SubstanceSpecification.structure.isotope.molecularWeight" />
1624         <min value="0" />
1625         <max value="1" />
1626       </base>
1627       <type>
1628         <code value="BackboneElement" />
1629       </type>
1630       <constraint>
1631         <key value="ele-1" />
1632         <severity value="error" />
1633         <human value="All FHIR elements must have a @value or children" />
1634         <expression value="hasValue() or (children().count() > id.count())" />
1635         <xpath value="@value|f:*|h:div" />
1636         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1637       </constraint>
1638       <isModifier value="false" />
1639       <isSummary value="true" />
1640     </element>
1641     <element id="SubstanceSpecification.structure.isotope.molecularWeight.id">
1642       <path value="SubstanceSpecification.structure.isotope.molecularWeight.id" />
1643       <representation value="xmlAttr" />
1644       <short value="Unique id for inter-element referencing" />
1645       <definition value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." />
1646       <min value="0" />
1647       <max value="1" />
1648       <base>
1649         <path value="Element.id" />
1650         <min value="0" />
1651         <max value="1" />
1652       </base>
1653       <type>
1654         <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
1655           <valueUrl value="string" />
1656         </extension>
1657         <code value="http://hl7.org/fhirpath/System.String" />
1658       </type>
1659       <isModifier value="false" />
1660       <isSummary value="false" />
1661       <mapping>
1662         <identity value="rim" />
1663         <map value="n/a" />
1664       </mapping>
1665     </element>
1666     <element id="SubstanceSpecification.structure.isotope.molecularWeight.extension">
1667       <path value="SubstanceSpecification.structure.isotope.molecularWeight.extension" />
1668       <short value="Additional content defined by implementations" />
1669       <definition value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." />
1670       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
1671       <alias value="extensions" />
1672       <alias value="user content" />
1673       <min value="0" />
1674       <max value="*" />
1675       <base>
1676         <path value="Element.extension" />
1677         <min value="0" />
1678         <max value="*" />
1679       </base>
1680       <type>
1681         <code value="Extension" />
1682       </type>
1683       <constraint>
1684         <key value="ele-1" />
1685         <severity value="error" />
1686         <human value="All FHIR elements must have a @value or children" />
1687         <expression value="hasValue() or (children().count() > id.count())" />
1688         <xpath value="@value|f:*|h:div" />
1689         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1690       </constraint>
1691       <constraint>
1692         <key value="ext-1" />
1693         <severity value="error" />
1694         <human value="Must have either extensions or value[x], not both" />
1695         <expression value="extension.exists() != value.exists()" />
1696         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
1697         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
1698       </constraint>
1699       <isModifier value="false" />
1700       <isSummary value="false" />
1701       <mapping>
1702         <identity value="rim" />
1703         <map value="n/a" />
1704       </mapping>
1705     </element>
1706     <element id="SubstanceSpecification.structure.isotope.molecularWeight.modifierExtension">
1707       <path value="SubstanceSpecification.structure.isotope.molecularWeight.modifierExtension" />
1708       <short value="Extensions that cannot be ignored even if unrecognized" />
1709       <definition value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)." />
1710       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
1711       <requirements value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](extensibility.html#modifierExtension)." />
1712       <alias value="extensions" />
1713       <alias value="user content" />
1714       <alias value="modifiers" />
1715       <min value="0" />
1716       <max value="*" />
1717       <base>
1718         <path value="BackboneElement.modifierExtension" />
1719         <min value="0" />
1720         <max value="*" />
1721       </base>
1722       <type>
1723         <code value="Extension" />
1724       </type>
1725       <constraint>
1726         <key value="ele-1" />
1727         <severity value="error" />
1728         <human value="All FHIR elements must have a @value or children" />
1729         <expression value="hasValue() or (children().count() > id.count())" />
1730         <xpath value="@value|f:*|h:div" />
1731         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1732       </constraint>
1733       <constraint>
1734         <key value="ext-1" />
1735         <severity value="error" />
1736         <human value="Must have either extensions or value[x], not both" />
1737         <expression value="extension.exists() != value.exists()" />
1738         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
1739         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
1740       </constraint>
1741       <isModifier value="true" />
1742       <isModifierReason value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them" />
1743       <isSummary value="true" />
1744       <mapping>
1745         <identity value="rim" />
1746         <map value="N/A" />
1747       </mapping>
1748     </element>
1749     <element id="SubstanceSpecification.structure.isotope.molecularWeight.method">
1750       <path value="SubstanceSpecification.structure.isotope.molecularWeight.method" />
1751       <short value="The method by which the molecular weight was determined" />
1752       <definition value="The method by which the molecular weight was determined." />
1753       <min value="0" />
1754       <max value="1" />
1755       <base>
1756         <path value="SubstanceSpecification.structure.isotope.molecularWeight.method" />
1757         <min value="0" />
1758         <max value="1" />
1759       </base>
1760       <type>
1761         <code value="CodeableConcept" />
1762       </type>
1763       <constraint>
1764         <key value="ele-1" />
1765         <severity value="error" />
1766         <human value="All FHIR elements must have a @value or children" />
1767         <expression value="hasValue() or (children().count() > id.count())" />
1768         <xpath value="@value|f:*|h:div" />
1769         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1770       </constraint>
1771       <isModifier value="false" />
1772       <isSummary value="true" />
1773     </element>
1774     <element id="SubstanceSpecification.structure.isotope.molecularWeight.type">
1775       <path value="SubstanceSpecification.structure.isotope.molecularWeight.type" />
1776       <short value="Type of molecular weight such as exact, average (also known as. number average), weight average" />
1777       <definition value="Type of molecular weight such as exact, average (also known as. number average), weight average." />
1778       <min value="0" />
1779       <max value="1" />
1780       <base>
1781         <path value="SubstanceSpecification.structure.isotope.molecularWeight.type" />
1782         <min value="0" />
1783         <max value="1" />
1784       </base>
1785       <type>
1786         <code value="CodeableConcept" />
1787       </type>
1788       <constraint>
1789         <key value="ele-1" />
1790         <severity value="error" />
1791         <human value="All FHIR elements must have a @value or children" />
1792         <expression value="hasValue() or (children().count() > id.count())" />
1793         <xpath value="@value|f:*|h:div" />
1794         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1795       </constraint>
1796       <isModifier value="false" />
1797       <isSummary value="true" />
1798     </element>
1799     <element id="SubstanceSpecification.structure.isotope.molecularWeight.amount">
1800       <path value="SubstanceSpecification.structure.isotope.molecularWeight.amount" />
1801       <short value="Used to capture quantitative values for a variety of elements. If only limits are given, the arithmetic mean would be the average. If only a single definite value for a given element is given, it would be captured in this field" />
1802       <definition value="Used to capture quantitative values for a variety of elements. If only limits are given, the arithmetic mean would be the average. If only a single definite value for a given element is given, it would be captured in this field." />
1803       <min value="0" />
1804       <max value="1" />
1805       <base>
1806         <path value="SubstanceSpecification.structure.isotope.molecularWeight.amount" />
1807         <min value="0" />
1808         <max value="1" />
1809       </base>
1810       <type>
1811         <code value="Quantity" />
1812       </type>
1813       <constraint>
1814         <key value="ele-1" />
1815         <severity value="error" />
1816         <human value="All FHIR elements must have a @value or children" />
1817         <expression value="hasValue() or (children().count() > id.count())" />
1818         <xpath value="@value|f:*|h:div" />
1819         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1820       </constraint>
1821       <isModifier value="false" />
1822       <isSummary value="true" />
1823     </element>
1824     <element id="SubstanceSpecification.structure.molecularWeight">
1825       <path value="SubstanceSpecification.structure.molecularWeight" />
1826       <short value="The molecular weight or weight range (for proteins, polymers or nucleic acids)" />
1827       <definition value="The molecular weight or weight range (for proteins, polymers or nucleic acids)." />
1828       <min value="0" />
1829       <max value="1" />
1830       <base>
1831         <path value="SubstanceSpecification.structure.molecularWeight" />
1832         <min value="0" />
1833         <max value="1" />
1834       </base>
1835       <contentReference value="#SubstanceSpecification.structure.isotope.molecularWeight" />
1836       <constraint>
1837         <key value="ele-1" />
1838         <severity value="error" />
1839         <human value="All FHIR elements must have a @value or children" />
1840         <expression value="hasValue() or (children().count() > id.count())" />
1841         <xpath value="@value|f:*|h:div" />
1842         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1843       </constraint>
1844       <isModifier value="false" />
1845       <isSummary value="true" />
1846     </element>
1847     <element id="SubstanceSpecification.structure.source">
1848       <path value="SubstanceSpecification.structure.source" />
1849       <short value="Supporting literature" />
1850       <definition value="Supporting literature." />
1851       <min value="0" />
1852       <max value="*" />
1853       <base>
1854         <path value="SubstanceSpecification.structure.source" />
1855         <min value="0" />
1856         <max value="*" />
1857       </base>
1858       <type>
1859         <code value="Reference" />
1860         <targetProfile value="http://hl7.org/fhir/StructureDefinition/DocumentReference" />
1861       </type>
1862       <constraint>
1863         <key value="ele-1" />
1864         <severity value="error" />
1865         <human value="All FHIR elements must have a @value or children" />
1866         <expression value="hasValue() or (children().count() > id.count())" />
1867         <xpath value="@value|f:*|h:div" />
1868         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1869       </constraint>
1870       <isModifier value="false" />
1871       <isSummary value="true" />
1872     </element>
1873     <element id="SubstanceSpecification.structure.representation">
1874       <path value="SubstanceSpecification.structure.representation" />
1875       <short value="Molecular structural representation" />
1876       <definition value="Molecular structural representation." />
1877       <min value="0" />
1878       <max value="*" />
1879       <base>
1880         <path value="SubstanceSpecification.structure.representation" />
1881         <min value="0" />
1882         <max value="*" />
1883       </base>
1884       <type>
1885         <code value="BackboneElement" />
1886       </type>
1887       <constraint>
1888         <key value="ele-1" />
1889         <severity value="error" />
1890         <human value="All FHIR elements must have a @value or children" />
1891         <expression value="hasValue() or (children().count() > id.count())" />
1892         <xpath value="@value|f:*|h:div" />
1893         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1894       </constraint>
1895       <isModifier value="false" />
1896       <isSummary value="true" />
1897     </element>
1898     <element id="SubstanceSpecification.structure.representation.id">
1899       <path value="SubstanceSpecification.structure.representation.id" />
1900       <representation value="xmlAttr" />
1901       <short value="Unique id for inter-element referencing" />
1902       <definition value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." />
1903       <min value="0" />
1904       <max value="1" />
1905       <base>
1906         <path value="Element.id" />
1907         <min value="0" />
1908         <max value="1" />
1909       </base>
1910       <type>
1911         <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
1912           <valueUrl value="string" />
1913         </extension>
1914         <code value="http://hl7.org/fhirpath/System.String" />
1915       </type>
1916       <isModifier value="false" />
1917       <isSummary value="false" />
1918       <mapping>
1919         <identity value="rim" />
1920         <map value="n/a" />
1921       </mapping>
1922     </element>
1923     <element id="SubstanceSpecification.structure.representation.extension">
1924       <path value="SubstanceSpecification.structure.representation.extension" />
1925       <short value="Additional content defined by implementations" />
1926       <definition value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." />
1927       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
1928       <alias value="extensions" />
1929       <alias value="user content" />
1930       <min value="0" />
1931       <max value="*" />
1932       <base>
1933         <path value="Element.extension" />
1934         <min value="0" />
1935         <max value="*" />
1936       </base>
1937       <type>
1938         <code value="Extension" />
1939       </type>
1940       <constraint>
1941         <key value="ele-1" />
1942         <severity value="error" />
1943         <human value="All FHIR elements must have a @value or children" />
1944         <expression value="hasValue() or (children().count() > id.count())" />
1945         <xpath value="@value|f:*|h:div" />
1946         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1947       </constraint>
1948       <constraint>
1949         <key value="ext-1" />
1950         <severity value="error" />
1951         <human value="Must have either extensions or value[x], not both" />
1952         <expression value="extension.exists() != value.exists()" />
1953         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
1954         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
1955       </constraint>
1956       <isModifier value="false" />
1957       <isSummary value="false" />
1958       <mapping>
1959         <identity value="rim" />
1960         <map value="n/a" />
1961       </mapping>
1962     </element>
1963     <element id="SubstanceSpecification.structure.representation.modifierExtension">
1964       <path value="SubstanceSpecification.structure.representation.modifierExtension" />
1965       <short value="Extensions that cannot be ignored even if unrecognized" />
1966       <definition value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)." />
1967       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
1968       <requirements value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](extensibility.html#modifierExtension)." />
1969       <alias value="extensions" />
1970       <alias value="user content" />
1971       <alias value="modifiers" />
1972       <min value="0" />
1973       <max value="*" />
1974       <base>
1975         <path value="BackboneElement.modifierExtension" />
1976         <min value="0" />
1977         <max value="*" />
1978       </base>
1979       <type>
1980         <code value="Extension" />
1981       </type>
1982       <constraint>
1983         <key value="ele-1" />
1984         <severity value="error" />
1985         <human value="All FHIR elements must have a @value or children" />
1986         <expression value="hasValue() or (children().count() > id.count())" />
1987         <xpath value="@value|f:*|h:div" />
1988         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
1989       </constraint>
1990       <constraint>
1991         <key value="ext-1" />
1992         <severity value="error" />
1993         <human value="Must have either extensions or value[x], not both" />
1994         <expression value="extension.exists() != value.exists()" />
1995         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
1996         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
1997       </constraint>
1998       <isModifier value="true" />
1999       <isModifierReason value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them" />
2000       <isSummary value="true" />
2001       <mapping>
2002         <identity value="rim" />
2003         <map value="N/A" />
2004       </mapping>
2005     </element>
2006     <element id="SubstanceSpecification.structure.representation.type">
2007       <path value="SubstanceSpecification.structure.representation.type" />
2008       <short value="The type of structure (e.g. Full, Partial, Representative)" />
2009       <definition value="The type of structure (e.g. Full, Partial, Representative)." />
2010       <min value="0" />
2011       <max value="1" />
2012       <base>
2013         <path value="SubstanceSpecification.structure.representation.type" />
2014         <min value="0" />
2015         <max value="1" />
2016       </base>
2017       <type>
2018         <code value="CodeableConcept" />
2019       </type>
2020       <constraint>
2021         <key value="ele-1" />
2022         <severity value="error" />
2023         <human value="All FHIR elements must have a @value or children" />
2024         <expression value="hasValue() or (children().count() > id.count())" />
2025         <xpath value="@value|f:*|h:div" />
2026         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2027       </constraint>
2028       <isModifier value="false" />
2029       <isSummary value="true" />
2030     </element>
2031     <element id="SubstanceSpecification.structure.representation.representation">
2032       <path value="SubstanceSpecification.structure.representation.representation" />
2033       <short value="The structural representation as text string in a format e.g. InChI, SMILES, MOLFILE, CDX" />
2034       <definition value="The structural representation as text string in a format e.g. InChI, SMILES, MOLFILE, CDX." />
2035       <min value="0" />
2036       <max value="1" />
2037       <base>
2038         <path value="SubstanceSpecification.structure.representation.representation" />
2039         <min value="0" />
2040         <max value="1" />
2041       </base>
2042       <type>
2043         <code value="string" />
2044       </type>
2045       <constraint>
2046         <key value="ele-1" />
2047         <severity value="error" />
2048         <human value="All FHIR elements must have a @value or children" />
2049         <expression value="hasValue() or (children().count() > id.count())" />
2050         <xpath value="@value|f:*|h:div" />
2051         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2052       </constraint>
2053       <isModifier value="false" />
2054       <isSummary value="true" />
2055     </element>
2056     <element id="SubstanceSpecification.structure.representation.attachment">
2057       <path value="SubstanceSpecification.structure.representation.attachment" />
2058       <short value="An attached file with the structural representation" />
2059       <definition value="An attached file with the structural representation." />
2060       <min value="0" />
2061       <max value="1" />
2062       <base>
2063         <path value="SubstanceSpecification.structure.representation.attachment" />
2064         <min value="0" />
2065         <max value="1" />
2066       </base>
2067       <type>
2068         <code value="Attachment" />
2069       </type>
2070       <constraint>
2071         <key value="ele-1" />
2072         <severity value="error" />
2073         <human value="All FHIR elements must have a @value or children" />
2074         <expression value="hasValue() or (children().count() > id.count())" />
2075         <xpath value="@value|f:*|h:div" />
2076         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2077       </constraint>
2078       <isModifier value="false" />
2079       <isSummary value="true" />
2080     </element>
2081     <element id="SubstanceSpecification.code">
2082       <path value="SubstanceSpecification.code" />
2083       <short value="Codes associated with the substance" />
2084       <definition value="Codes associated with the substance." />
2085       <min value="0" />
2086       <max value="*" />
2087       <base>
2088         <path value="SubstanceSpecification.code" />
2089         <min value="0" />
2090         <max value="*" />
2091       </base>
2092       <type>
2093         <code value="BackboneElement" />
2094       </type>
2095       <constraint>
2096         <key value="ele-1" />
2097         <severity value="error" />
2098         <human value="All FHIR elements must have a @value or children" />
2099         <expression value="hasValue() or (children().count() > id.count())" />
2100         <xpath value="@value|f:*|h:div" />
2101         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2102       </constraint>
2103       <isModifier value="false" />
2104       <isSummary value="true" />
2105     </element>
2106     <element id="SubstanceSpecification.code.id">
2107       <path value="SubstanceSpecification.code.id" />
2108       <representation value="xmlAttr" />
2109       <short value="Unique id for inter-element referencing" />
2110       <definition value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." />
2111       <min value="0" />
2112       <max value="1" />
2113       <base>
2114         <path value="Element.id" />
2115         <min value="0" />
2116         <max value="1" />
2117       </base>
2118       <type>
2119         <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
2120           <valueUrl value="string" />
2121         </extension>
2122         <code value="http://hl7.org/fhirpath/System.String" />
2123       </type>
2124       <isModifier value="false" />
2125       <isSummary value="false" />
2126       <mapping>
2127         <identity value="rim" />
2128         <map value="n/a" />
2129       </mapping>
2130     </element>
2131     <element id="SubstanceSpecification.code.extension">
2132       <path value="SubstanceSpecification.code.extension" />
2133       <short value="Additional content defined by implementations" />
2134       <definition value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." />
2135       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
2136       <alias value="extensions" />
2137       <alias value="user content" />
2138       <min value="0" />
2139       <max value="*" />
2140       <base>
2141         <path value="Element.extension" />
2142         <min value="0" />
2143         <max value="*" />
2144       </base>
2145       <type>
2146         <code value="Extension" />
2147       </type>
2148       <constraint>
2149         <key value="ele-1" />
2150         <severity value="error" />
2151         <human value="All FHIR elements must have a @value or children" />
2152         <expression value="hasValue() or (children().count() > id.count())" />
2153         <xpath value="@value|f:*|h:div" />
2154         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2155       </constraint>
2156       <constraint>
2157         <key value="ext-1" />
2158         <severity value="error" />
2159         <human value="Must have either extensions or value[x], not both" />
2160         <expression value="extension.exists() != value.exists()" />
2161         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
2162         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
2163       </constraint>
2164       <isModifier value="false" />
2165       <isSummary value="false" />
2166       <mapping>
2167         <identity value="rim" />
2168         <map value="n/a" />
2169       </mapping>
2170     </element>
2171     <element id="SubstanceSpecification.code.modifierExtension">
2172       <path value="SubstanceSpecification.code.modifierExtension" />
2173       <short value="Extensions that cannot be ignored even if unrecognized" />
2174       <definition value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)." />
2175       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
2176       <requirements value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](extensibility.html#modifierExtension)." />
2177       <alias value="extensions" />
2178       <alias value="user content" />
2179       <alias value="modifiers" />
2180       <min value="0" />
2181       <max value="*" />
2182       <base>
2183         <path value="BackboneElement.modifierExtension" />
2184         <min value="0" />
2185         <max value="*" />
2186       </base>
2187       <type>
2188         <code value="Extension" />
2189       </type>
2190       <constraint>
2191         <key value="ele-1" />
2192         <severity value="error" />
2193         <human value="All FHIR elements must have a @value or children" />
2194         <expression value="hasValue() or (children().count() > id.count())" />
2195         <xpath value="@value|f:*|h:div" />
2196         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2197       </constraint>
2198       <constraint>
2199         <key value="ext-1" />
2200         <severity value="error" />
2201         <human value="Must have either extensions or value[x], not both" />
2202         <expression value="extension.exists() != value.exists()" />
2203         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
2204         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
2205       </constraint>
2206       <isModifier value="true" />
2207       <isModifierReason value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them" />
2208       <isSummary value="true" />
2209       <mapping>
2210         <identity value="rim" />
2211         <map value="N/A" />
2212       </mapping>
2213     </element>
2214     <element id="SubstanceSpecification.code.code">
2215       <path value="SubstanceSpecification.code.code" />
2216       <short value="The specific code" />
2217       <definition value="The specific code." />
2218       <min value="0" />
2219       <max value="1" />
2220       <base>
2221         <path value="SubstanceSpecification.code.code" />
2222         <min value="0" />
2223         <max value="1" />
2224       </base>
2225       <type>
2226         <code value="CodeableConcept" />
2227       </type>
2228       <constraint>
2229         <key value="ele-1" />
2230         <severity value="error" />
2231         <human value="All FHIR elements must have a @value or children" />
2232         <expression value="hasValue() or (children().count() > id.count())" />
2233         <xpath value="@value|f:*|h:div" />
2234         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2235       </constraint>
2236       <isModifier value="false" />
2237       <isSummary value="true" />
2238     </element>
2239     <element id="SubstanceSpecification.code.status">
2240       <path value="SubstanceSpecification.code.status" />
2241       <short value="Status of the code assignment" />
2242       <definition value="Status of the code assignment." />
2243       <min value="0" />
2244       <max value="1" />
2245       <base>
2246         <path value="SubstanceSpecification.code.status" />
2247         <min value="0" />
2248         <max value="1" />
2249       </base>
2250       <type>
2251         <code value="CodeableConcept" />
2252       </type>
2253       <constraint>
2254         <key value="ele-1" />
2255         <severity value="error" />
2256         <human value="All FHIR elements must have a @value or children" />
2257         <expression value="hasValue() or (children().count() > id.count())" />
2258         <xpath value="@value|f:*|h:div" />
2259         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2260       </constraint>
2261       <isModifier value="false" />
2262       <isSummary value="true" />
2263     </element>
2264     <element id="SubstanceSpecification.code.statusDate">
2265       <path value="SubstanceSpecification.code.statusDate" />
2266       <short value="The date at which the code status is changed as part of the terminology maintenance" />
2267       <definition value="The date at which the code status is changed as part of the terminology maintenance." />
2268       <min value="0" />
2269       <max value="1" />
2270       <base>
2271         <path value="SubstanceSpecification.code.statusDate" />
2272         <min value="0" />
2273         <max value="1" />
2274       </base>
2275       <type>
2276         <code value="dateTime" />
2277       </type>
2278       <constraint>
2279         <key value="ele-1" />
2280         <severity value="error" />
2281         <human value="All FHIR elements must have a @value or children" />
2282         <expression value="hasValue() or (children().count() > id.count())" />
2283         <xpath value="@value|f:*|h:div" />
2284         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2285       </constraint>
2286       <isModifier value="false" />
2287       <isSummary value="true" />
2288     </element>
2289     <element id="SubstanceSpecification.code.comment">
2290       <path value="SubstanceSpecification.code.comment" />
2291       <short value="Any comment can be provided in this field, if necessary" />
2292       <definition value="Any comment can be provided in this field, if necessary." />
2293       <min value="0" />
2294       <max value="1" />
2295       <base>
2296         <path value="SubstanceSpecification.code.comment" />
2297         <min value="0" />
2298         <max value="1" />
2299       </base>
2300       <type>
2301         <code value="string" />
2302       </type>
2303       <constraint>
2304         <key value="ele-1" />
2305         <severity value="error" />
2306         <human value="All FHIR elements must have a @value or children" />
2307         <expression value="hasValue() or (children().count() > id.count())" />
2308         <xpath value="@value|f:*|h:div" />
2309         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2310       </constraint>
2311       <isModifier value="false" />
2312       <isSummary value="true" />
2313     </element>
2314     <element id="SubstanceSpecification.code.source">
2315       <path value="SubstanceSpecification.code.source" />
2316       <short value="Supporting literature" />
2317       <definition value="Supporting literature." />
2318       <min value="0" />
2319       <max value="*" />
2320       <base>
2321         <path value="SubstanceSpecification.code.source" />
2322         <min value="0" />
2323         <max value="*" />
2324       </base>
2325       <type>
2326         <code value="Reference" />
2327         <targetProfile value="http://hl7.org/fhir/StructureDefinition/DocumentReference" />
2328       </type>
2329       <constraint>
2330         <key value="ele-1" />
2331         <severity value="error" />
2332         <human value="All FHIR elements must have a @value or children" />
2333         <expression value="hasValue() or (children().count() > id.count())" />
2334         <xpath value="@value|f:*|h:div" />
2335         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2336       </constraint>
2337       <isModifier value="false" />
2338       <isSummary value="true" />
2339     </element>
2340     <element id="SubstanceSpecification.name">
2341       <path value="SubstanceSpecification.name" />
2342       <short value="Names applicable to this substance" />
2343       <definition value="Names applicable to this substance." />
2344       <min value="0" />
2345       <max value="*" />
2346       <base>
2347         <path value="SubstanceSpecification.name" />
2348         <min value="0" />
2349         <max value="*" />
2350       </base>
2351       <type>
2352         <code value="BackboneElement" />
2353       </type>
2354       <constraint>
2355         <key value="ele-1" />
2356         <severity value="error" />
2357         <human value="All FHIR elements must have a @value or children" />
2358         <expression value="hasValue() or (children().count() > id.count())" />
2359         <xpath value="@value|f:*|h:div" />
2360         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2361       </constraint>
2362       <isModifier value="false" />
2363       <isSummary value="true" />
2364     </element>
2365     <element id="SubstanceSpecification.name.id">
2366       <path value="SubstanceSpecification.name.id" />
2367       <representation value="xmlAttr" />
2368       <short value="Unique id for inter-element referencing" />
2369       <definition value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." />
2370       <min value="0" />
2371       <max value="1" />
2372       <base>
2373         <path value="Element.id" />
2374         <min value="0" />
2375         <max value="1" />
2376       </base>
2377       <type>
2378         <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
2379           <valueUrl value="string" />
2380         </extension>
2381         <code value="http://hl7.org/fhirpath/System.String" />
2382       </type>
2383       <isModifier value="false" />
2384       <isSummary value="false" />
2385       <mapping>
2386         <identity value="rim" />
2387         <map value="n/a" />
2388       </mapping>
2389     </element>
2390     <element id="SubstanceSpecification.name.extension">
2391       <path value="SubstanceSpecification.name.extension" />
2392       <short value="Additional content defined by implementations" />
2393       <definition value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." />
2394       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
2395       <alias value="extensions" />
2396       <alias value="user content" />
2397       <min value="0" />
2398       <max value="*" />
2399       <base>
2400         <path value="Element.extension" />
2401         <min value="0" />
2402         <max value="*" />
2403       </base>
2404       <type>
2405         <code value="Extension" />
2406       </type>
2407       <constraint>
2408         <key value="ele-1" />
2409         <severity value="error" />
2410         <human value="All FHIR elements must have a @value or children" />
2411         <expression value="hasValue() or (children().count() > id.count())" />
2412         <xpath value="@value|f:*|h:div" />
2413         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2414       </constraint>
2415       <constraint>
2416         <key value="ext-1" />
2417         <severity value="error" />
2418         <human value="Must have either extensions or value[x], not both" />
2419         <expression value="extension.exists() != value.exists()" />
2420         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
2421         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
2422       </constraint>
2423       <isModifier value="false" />
2424       <isSummary value="false" />
2425       <mapping>
2426         <identity value="rim" />
2427         <map value="n/a" />
2428       </mapping>
2429     </element>
2430     <element id="SubstanceSpecification.name.modifierExtension">
2431       <path value="SubstanceSpecification.name.modifierExtension" />
2432       <short value="Extensions that cannot be ignored even if unrecognized" />
2433       <definition value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)." />
2434       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
2435       <requirements value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](extensibility.html#modifierExtension)." />
2436       <alias value="extensions" />
2437       <alias value="user content" />
2438       <alias value="modifiers" />
2439       <min value="0" />
2440       <max value="*" />
2441       <base>
2442         <path value="BackboneElement.modifierExtension" />
2443         <min value="0" />
2444         <max value="*" />
2445       </base>
2446       <type>
2447         <code value="Extension" />
2448       </type>
2449       <constraint>
2450         <key value="ele-1" />
2451         <severity value="error" />
2452         <human value="All FHIR elements must have a @value or children" />
2453         <expression value="hasValue() or (children().count() > id.count())" />
2454         <xpath value="@value|f:*|h:div" />
2455         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2456       </constraint>
2457       <constraint>
2458         <key value="ext-1" />
2459         <severity value="error" />
2460         <human value="Must have either extensions or value[x], not both" />
2461         <expression value="extension.exists() != value.exists()" />
2462         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
2463         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
2464       </constraint>
2465       <isModifier value="true" />
2466       <isModifierReason value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them" />
2467       <isSummary value="true" />
2468       <mapping>
2469         <identity value="rim" />
2470         <map value="N/A" />
2471       </mapping>
2472     </element>
2473     <element id="SubstanceSpecification.name.name">
2474       <path value="SubstanceSpecification.name.name" />
2475       <short value="The actual name" />
2476       <definition value="The actual name." />
2477       <min value="1" />
2478       <max value="1" />
2479       <base>
2480         <path value="SubstanceSpecification.name.name" />
2481         <min value="1" />
2482         <max value="1" />
2483       </base>
2484       <type>
2485         <code value="string" />
2486       </type>
2487       <constraint>
2488         <key value="ele-1" />
2489         <severity value="error" />
2490         <human value="All FHIR elements must have a @value or children" />
2491         <expression value="hasValue() or (children().count() > id.count())" />
2492         <xpath value="@value|f:*|h:div" />
2493         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2494       </constraint>
2495       <isModifier value="false" />
2496       <isSummary value="true" />
2497     </element>
2498     <element id="SubstanceSpecification.name.type">
2499       <path value="SubstanceSpecification.name.type" />
2500       <short value="Name type" />
2501       <definition value="Name type." />
2502       <min value="0" />
2503       <max value="1" />
2504       <base>
2505         <path value="SubstanceSpecification.name.type" />
2506         <min value="0" />
2507         <max value="1" />
2508       </base>
2509       <type>
2510         <code value="CodeableConcept" />
2511       </type>
2512       <constraint>
2513         <key value="ele-1" />
2514         <severity value="error" />
2515         <human value="All FHIR elements must have a @value or children" />
2516         <expression value="hasValue() or (children().count() > id.count())" />
2517         <xpath value="@value|f:*|h:div" />
2518         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2519       </constraint>
2520       <isModifier value="false" />
2521       <isSummary value="true" />
2522     </element>
2523     <element id="SubstanceSpecification.name.status">
2524       <path value="SubstanceSpecification.name.status" />
2525       <short value="The status of the name" />
2526       <definition value="The status of the name." />
2527       <min value="0" />
2528       <max value="1" />
2529       <base>
2530         <path value="SubstanceSpecification.name.status" />
2531         <min value="0" />
2532         <max value="1" />
2533       </base>
2534       <type>
2535         <code value="CodeableConcept" />
2536       </type>
2537       <constraint>
2538         <key value="ele-1" />
2539         <severity value="error" />
2540         <human value="All FHIR elements must have a @value or children" />
2541         <expression value="hasValue() or (children().count() > id.count())" />
2542         <xpath value="@value|f:*|h:div" />
2543         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2544       </constraint>
2545       <isModifier value="false" />
2546       <isSummary value="true" />
2547     </element>
2548     <element id="SubstanceSpecification.name.preferred">
2549       <path value="SubstanceSpecification.name.preferred" />
2550       <short value="If this is the preferred name for this substance" />
2551       <definition value="If this is the preferred name for this substance." />
2552       <min value="0" />
2553       <max value="1" />
2554       <base>
2555         <path value="SubstanceSpecification.name.preferred" />
2556         <min value="0" />
2557         <max value="1" />
2558       </base>
2559       <type>
2560         <code value="boolean" />
2561       </type>
2562       <constraint>
2563         <key value="ele-1" />
2564         <severity value="error" />
2565         <human value="All FHIR elements must have a @value or children" />
2566         <expression value="hasValue() or (children().count() > id.count())" />
2567         <xpath value="@value|f:*|h:div" />
2568         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2569       </constraint>
2570       <isModifier value="false" />
2571       <isSummary value="true" />
2572     </element>
2573     <element id="SubstanceSpecification.name.language">
2574       <path value="SubstanceSpecification.name.language" />
2575       <short value="Language of the name" />
2576       <definition value="Language of the name." />
2577       <min value="0" />
2578       <max value="*" />
2579       <base>
2580         <path value="SubstanceSpecification.name.language" />
2581         <min value="0" />
2582         <max value="*" />
2583       </base>
2584       <type>
2585         <code value="CodeableConcept" />
2586       </type>
2587       <constraint>
2588         <key value="ele-1" />
2589         <severity value="error" />
2590         <human value="All FHIR elements must have a @value or children" />
2591         <expression value="hasValue() or (children().count() > id.count())" />
2592         <xpath value="@value|f:*|h:div" />
2593         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2594       </constraint>
2595       <isModifier value="false" />
2596       <isSummary value="true" />
2597     </element>
2598     <element id="SubstanceSpecification.name.domain">
2599       <path value="SubstanceSpecification.name.domain" />
2600       <short value="The use context of this name for example if there is a different name a drug active ingredient as opposed to a food colour additive" />
2601       <definition value="The use context of this name for example if there is a different name a drug active ingredient as opposed to a food colour additive." />
2602       <min value="0" />
2603       <max value="*" />
2604       <base>
2605         <path value="SubstanceSpecification.name.domain" />
2606         <min value="0" />
2607         <max value="*" />
2608       </base>
2609       <type>
2610         <code value="CodeableConcept" />
2611       </type>
2612       <constraint>
2613         <key value="ele-1" />
2614         <severity value="error" />
2615         <human value="All FHIR elements must have a @value or children" />
2616         <expression value="hasValue() or (children().count() > id.count())" />
2617         <xpath value="@value|f:*|h:div" />
2618         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2619       </constraint>
2620       <isModifier value="false" />
2621       <isSummary value="true" />
2622     </element>
2623     <element id="SubstanceSpecification.name.jurisdiction">
2624       <path value="SubstanceSpecification.name.jurisdiction" />
2625       <short value="The jurisdiction where this name applies" />
2626       <definition value="The jurisdiction where this name applies." />
2627       <min value="0" />
2628       <max value="*" />
2629       <base>
2630         <path value="SubstanceSpecification.name.jurisdiction" />
2631         <min value="0" />
2632         <max value="*" />
2633       </base>
2634       <type>
2635         <code value="CodeableConcept" />
2636       </type>
2637       <constraint>
2638         <key value="ele-1" />
2639         <severity value="error" />
2640         <human value="All FHIR elements must have a @value or children" />
2641         <expression value="hasValue() or (children().count() > id.count())" />
2642         <xpath value="@value|f:*|h:div" />
2643         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2644       </constraint>
2645       <isModifier value="false" />
2646       <isSummary value="true" />
2647     </element>
2648     <element id="SubstanceSpecification.name.synonym">
2649       <path value="SubstanceSpecification.name.synonym" />
2650       <short value="A synonym of this name" />
2651       <definition value="A synonym of this name." />
2652       <min value="0" />
2653       <max value="*" />
2654       <base>
2655         <path value="SubstanceSpecification.name.synonym" />
2656         <min value="0" />
2657         <max value="*" />
2658       </base>
2659       <contentReference value="#SubstanceSpecification.name" />
2660       <constraint>
2661         <key value="ele-1" />
2662         <severity value="error" />
2663         <human value="All FHIR elements must have a @value or children" />
2664         <expression value="hasValue() or (children().count() > id.count())" />
2665         <xpath value="@value|f:*|h:div" />
2666         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2667       </constraint>
2668       <isModifier value="false" />
2669       <isSummary value="true" />
2670     </element>
2671     <element id="SubstanceSpecification.name.translation">
2672       <path value="SubstanceSpecification.name.translation" />
2673       <short value="A translation for this name" />
2674       <definition value="A translation for this name." />
2675       <min value="0" />
2676       <max value="*" />
2677       <base>
2678         <path value="SubstanceSpecification.name.translation" />
2679         <min value="0" />
2680         <max value="*" />
2681       </base>
2682       <contentReference value="#SubstanceSpecification.name" />
2683       <constraint>
2684         <key value="ele-1" />
2685         <severity value="error" />
2686         <human value="All FHIR elements must have a @value or children" />
2687         <expression value="hasValue() or (children().count() > id.count())" />
2688         <xpath value="@value|f:*|h:div" />
2689         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2690       </constraint>
2691       <isModifier value="false" />
2692       <isSummary value="true" />
2693     </element>
2694     <element id="SubstanceSpecification.name.official">
2695       <path value="SubstanceSpecification.name.official" />
2696       <short value="Details of the official nature of this name" />
2697       <definition value="Details of the official nature of this name." />
2698       <min value="0" />
2699       <max value="*" />
2700       <base>
2701         <path value="SubstanceSpecification.name.official" />
2702         <min value="0" />
2703         <max value="*" />
2704       </base>
2705       <type>
2706         <code value="BackboneElement" />
2707       </type>
2708       <constraint>
2709         <key value="ele-1" />
2710         <severity value="error" />
2711         <human value="All FHIR elements must have a @value or children" />
2712         <expression value="hasValue() or (children().count() > id.count())" />
2713         <xpath value="@value|f:*|h:div" />
2714         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2715       </constraint>
2716       <isModifier value="false" />
2717       <isSummary value="true" />
2718     </element>
2719     <element id="SubstanceSpecification.name.official.id">
2720       <path value="SubstanceSpecification.name.official.id" />
2721       <representation value="xmlAttr" />
2722       <short value="Unique id for inter-element referencing" />
2723       <definition value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." />
2724       <min value="0" />
2725       <max value="1" />
2726       <base>
2727         <path value="Element.id" />
2728         <min value="0" />
2729         <max value="1" />
2730       </base>
2731       <type>
2732         <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
2733           <valueUrl value="string" />
2734         </extension>
2735         <code value="http://hl7.org/fhirpath/System.String" />
2736       </type>
2737       <isModifier value="false" />
2738       <isSummary value="false" />
2739       <mapping>
2740         <identity value="rim" />
2741         <map value="n/a" />
2742       </mapping>
2743     </element>
2744     <element id="SubstanceSpecification.name.official.extension">
2745       <path value="SubstanceSpecification.name.official.extension" />
2746       <short value="Additional content defined by implementations" />
2747       <definition value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." />
2748       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
2749       <alias value="extensions" />
2750       <alias value="user content" />
2751       <min value="0" />
2752       <max value="*" />
2753       <base>
2754         <path value="Element.extension" />
2755         <min value="0" />
2756         <max value="*" />
2757       </base>
2758       <type>
2759         <code value="Extension" />
2760       </type>
2761       <constraint>
2762         <key value="ele-1" />
2763         <severity value="error" />
2764         <human value="All FHIR elements must have a @value or children" />
2765         <expression value="hasValue() or (children().count() > id.count())" />
2766         <xpath value="@value|f:*|h:div" />
2767         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2768       </constraint>
2769       <constraint>
2770         <key value="ext-1" />
2771         <severity value="error" />
2772         <human value="Must have either extensions or value[x], not both" />
2773         <expression value="extension.exists() != value.exists()" />
2774         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
2775         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
2776       </constraint>
2777       <isModifier value="false" />
2778       <isSummary value="false" />
2779       <mapping>
2780         <identity value="rim" />
2781         <map value="n/a" />
2782       </mapping>
2783     </element>
2784     <element id="SubstanceSpecification.name.official.modifierExtension">
2785       <path value="SubstanceSpecification.name.official.modifierExtension" />
2786       <short value="Extensions that cannot be ignored even if unrecognized" />
2787       <definition value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)." />
2788       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
2789       <requirements value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](extensibility.html#modifierExtension)." />
2790       <alias value="extensions" />
2791       <alias value="user content" />
2792       <alias value="modifiers" />
2793       <min value="0" />
2794       <max value="*" />
2795       <base>
2796         <path value="BackboneElement.modifierExtension" />
2797         <min value="0" />
2798         <max value="*" />
2799       </base>
2800       <type>
2801         <code value="Extension" />
2802       </type>
2803       <constraint>
2804         <key value="ele-1" />
2805         <severity value="error" />
2806         <human value="All FHIR elements must have a @value or children" />
2807         <expression value="hasValue() or (children().count() > id.count())" />
2808         <xpath value="@value|f:*|h:div" />
2809         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2810       </constraint>
2811       <constraint>
2812         <key value="ext-1" />
2813         <severity value="error" />
2814         <human value="Must have either extensions or value[x], not both" />
2815         <expression value="extension.exists() != value.exists()" />
2816         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
2817         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
2818       </constraint>
2819       <isModifier value="true" />
2820       <isModifierReason value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them" />
2821       <isSummary value="true" />
2822       <mapping>
2823         <identity value="rim" />
2824         <map value="N/A" />
2825       </mapping>
2826     </element>
2827     <element id="SubstanceSpecification.name.official.authority">
2828       <path value="SubstanceSpecification.name.official.authority" />
2829       <short value="Which authority uses this official name" />
2830       <definition value="Which authority uses this official name." />
2831       <min value="0" />
2832       <max value="1" />
2833       <base>
2834         <path value="SubstanceSpecification.name.official.authority" />
2835         <min value="0" />
2836         <max value="1" />
2837       </base>
2838       <type>
2839         <code value="CodeableConcept" />
2840       </type>
2841       <constraint>
2842         <key value="ele-1" />
2843         <severity value="error" />
2844         <human value="All FHIR elements must have a @value or children" />
2845         <expression value="hasValue() or (children().count() > id.count())" />
2846         <xpath value="@value|f:*|h:div" />
2847         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2848       </constraint>
2849       <isModifier value="false" />
2850       <isSummary value="true" />
2851     </element>
2852     <element id="SubstanceSpecification.name.official.status">
2853       <path value="SubstanceSpecification.name.official.status" />
2854       <short value="The status of the official name" />
2855       <definition value="The status of the official name." />
2856       <min value="0" />
2857       <max value="1" />
2858       <base>
2859         <path value="SubstanceSpecification.name.official.status" />
2860         <min value="0" />
2861         <max value="1" />
2862       </base>
2863       <type>
2864         <code value="CodeableConcept" />
2865       </type>
2866       <constraint>
2867         <key value="ele-1" />
2868         <severity value="error" />
2869         <human value="All FHIR elements must have a @value or children" />
2870         <expression value="hasValue() or (children().count() > id.count())" />
2871         <xpath value="@value|f:*|h:div" />
2872         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2873       </constraint>
2874       <isModifier value="false" />
2875       <isSummary value="true" />
2876     </element>
2877     <element id="SubstanceSpecification.name.official.date">
2878       <path value="SubstanceSpecification.name.official.date" />
2879       <short value="Date of official name change" />
2880       <definition value="Date of official name change." />
2881       <min value="0" />
2882       <max value="1" />
2883       <base>
2884         <path value="SubstanceSpecification.name.official.date" />
2885         <min value="0" />
2886         <max value="1" />
2887       </base>
2888       <type>
2889         <code value="dateTime" />
2890       </type>
2891       <constraint>
2892         <key value="ele-1" />
2893         <severity value="error" />
2894         <human value="All FHIR elements must have a @value or children" />
2895         <expression value="hasValue() or (children().count() > id.count())" />
2896         <xpath value="@value|f:*|h:div" />
2897         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2898       </constraint>
2899       <isModifier value="false" />
2900       <isSummary value="true" />
2901     </element>
2902     <element id="SubstanceSpecification.name.source">
2903       <path value="SubstanceSpecification.name.source" />
2904       <short value="Supporting literature" />
2905       <definition value="Supporting literature." />
2906       <min value="0" />
2907       <max value="*" />
2908       <base>
2909         <path value="SubstanceSpecification.name.source" />
2910         <min value="0" />
2911         <max value="*" />
2912       </base>
2913       <type>
2914         <code value="Reference" />
2915         <targetProfile value="http://hl7.org/fhir/StructureDefinition/DocumentReference" />
2916       </type>
2917       <constraint>
2918         <key value="ele-1" />
2919         <severity value="error" />
2920         <human value="All FHIR elements must have a @value or children" />
2921         <expression value="hasValue() or (children().count() > id.count())" />
2922         <xpath value="@value|f:*|h:div" />
2923         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2924       </constraint>
2925       <isModifier value="false" />
2926       <isSummary value="true" />
2927     </element>
2928     <element id="SubstanceSpecification.molecularWeight">
2929       <path value="SubstanceSpecification.molecularWeight" />
2930       <short value="The molecular weight or weight range (for proteins, polymers or nucleic acids)" />
2931       <definition value="The molecular weight or weight range (for proteins, polymers or nucleic acids)." />
2932       <min value="0" />
2933       <max value="*" />
2934       <base>
2935         <path value="SubstanceSpecification.molecularWeight" />
2936         <min value="0" />
2937         <max value="*" />
2938       </base>
2939       <contentReference value="#SubstanceSpecification.structure.isotope.molecularWeight" />
2940       <constraint>
2941         <key value="ele-1" />
2942         <severity value="error" />
2943         <human value="All FHIR elements must have a @value or children" />
2944         <expression value="hasValue() or (children().count() > id.count())" />
2945         <xpath value="@value|f:*|h:div" />
2946         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2947       </constraint>
2948       <isModifier value="false" />
2949       <isSummary value="true" />
2950     </element>
2951     <element id="SubstanceSpecification.relationship">
2952       <path value="SubstanceSpecification.relationship" />
2953       <short value="A link between this substance and another, with details of the relationship" />
2954       <definition value="A link between this substance and another, with details of the relationship." />
2955       <min value="0" />
2956       <max value="*" />
2957       <base>
2958         <path value="SubstanceSpecification.relationship" />
2959         <min value="0" />
2960         <max value="*" />
2961       </base>
2962       <type>
2963         <code value="BackboneElement" />
2964       </type>
2965       <constraint>
2966         <key value="ele-1" />
2967         <severity value="error" />
2968         <human value="All FHIR elements must have a @value or children" />
2969         <expression value="hasValue() or (children().count() > id.count())" />
2970         <xpath value="@value|f:*|h:div" />
2971         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
2972       </constraint>
2973       <isModifier value="false" />
2974       <isSummary value="true" />
2975     </element>
2976     <element id="SubstanceSpecification.relationship.id">
2977       <path value="SubstanceSpecification.relationship.id" />
2978       <representation value="xmlAttr" />
2979       <short value="Unique id for inter-element referencing" />
2980       <definition value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." />
2981       <min value="0" />
2982       <max value="1" />
2983       <base>
2984         <path value="Element.id" />
2985         <min value="0" />
2986         <max value="1" />
2987       </base>
2988       <type>
2989         <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
2990           <valueUrl value="string" />
2991         </extension>
2992         <code value="http://hl7.org/fhirpath/System.String" />
2993       </type>
2994       <isModifier value="false" />
2995       <isSummary value="false" />
2996       <mapping>
2997         <identity value="rim" />
2998         <map value="n/a" />
2999       </mapping>
3000     </element>
3001     <element id="SubstanceSpecification.relationship.extension">
3002       <path value="SubstanceSpecification.relationship.extension" />
3003       <short value="Additional content defined by implementations" />
3004       <definition value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." />
3005       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
3006       <alias value="extensions" />
3007       <alias value="user content" />
3008       <min value="0" />
3009       <max value="*" />
3010       <base>
3011         <path value="Element.extension" />
3012         <min value="0" />
3013         <max value="*" />
3014       </base>
3015       <type>
3016         <code value="Extension" />
3017       </type>
3018       <constraint>
3019         <key value="ele-1" />
3020         <severity value="error" />
3021         <human value="All FHIR elements must have a @value or children" />
3022         <expression value="hasValue() or (children().count() > id.count())" />
3023         <xpath value="@value|f:*|h:div" />
3024         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
3025       </constraint>
3026       <constraint>
3027         <key value="ext-1" />
3028         <severity value="error" />
3029         <human value="Must have either extensions or value[x], not both" />
3030         <expression value="extension.exists() != value.exists()" />
3031         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
3032         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
3033       </constraint>
3034       <isModifier value="false" />
3035       <isSummary value="false" />
3036       <mapping>
3037         <identity value="rim" />
3038         <map value="n/a" />
3039       </mapping>
3040     </element>
3041     <element id="SubstanceSpecification.relationship.modifierExtension">
3042       <path value="SubstanceSpecification.relationship.modifierExtension" />
3043       <short value="Extensions that cannot be ignored even if unrecognized" />
3044       <definition value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)." />
3045       <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." />
3046       <requirements value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](extensibility.html#modifierExtension)." />
3047       <alias value="extensions" />
3048       <alias value="user content" />
3049       <alias value="modifiers" />
3050       <min value="0" />
3051       <max value="*" />
3052       <base>
3053         <path value="BackboneElement.modifierExtension" />
3054         <min value="0" />
3055         <max value="*" />
3056       </base>
3057       <type>
3058         <code value="Extension" />
3059       </type>
3060       <constraint>
3061         <key value="ele-1" />
3062         <severity value="error" />
3063         <human value="All FHIR elements must have a @value or children" />
3064         <expression value="hasValue() or (children().count() > id.count())" />
3065         <xpath value="@value|f:*|h:div" />
3066         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
3067       </constraint>
3068       <constraint>
3069         <key value="ext-1" />
3070         <severity value="error" />
3071         <human value="Must have either extensions or value[x], not both" />
3072         <expression value="extension.exists() != value.exists()" />
3073         <xpath value="exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])" />
3074         <source value="http://hl7.org/fhir/StructureDefinition/Extension" />
3075       </constraint>
3076       <isModifier value="true" />
3077       <isModifierReason value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them" />
3078       <isSummary value="true" />
3079       <mapping>
3080         <identity value="rim" />
3081         <map value="N/A" />
3082       </mapping>
3083     </element>
3084     <element id="SubstanceSpecification.relationship.substance[x]">
3085       <path value="SubstanceSpecification.relationship.substance[x]" />
3086       <short value="A pointer to another substance, as a resource or just a representational code" />
3087       <definition value="A pointer to another substance, as a resource or just a representational code." />
3088       <min value="0" />
3089       <max value="1" />
3090       <base>
3091         <path value="SubstanceSpecification.relationship.substance[x]" />
3092         <min value="0" />
3093         <max value="1" />
3094       </base>
3095       <type>
3096         <code value="Reference" />
3097         <targetProfile value="http://hl7.org/fhir/StructureDefinition/SubstanceSpecification" />
3098       </type>
3099       <type>
3100         <code value="CodeableConcept" />
3101       </type>
3102       <constraint>
3103         <key value="ele-1" />
3104         <severity value="error" />
3105         <human value="All FHIR elements must have a @value or children" />
3106         <expression value="hasValue() or (children().count() > id.count())" />
3107         <xpath value="@value|f:*|h:div" />
3108         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
3109       </constraint>
3110       <isModifier value="false" />
3111       <isSummary value="true" />
3112     </element>
3113     <element id="SubstanceSpecification.relationship.relationship">
3114       <path value="SubstanceSpecification.relationship.relationship" />
3115       <short value="For example "salt to parent", "active moiety", "starting material"" />
3116       <definition value="For example "salt to parent", "active moiety", "starting material"." />
3117       <min value="0" />
3118       <max value="1" />
3119       <base>
3120         <path value="SubstanceSpecification.relationship.relationship" />
3121         <min value="0" />
3122         <max value="1" />
3123       </base>
3124       <type>
3125         <code value="CodeableConcept" />
3126       </type>
3127       <constraint>
3128         <key value="ele-1" />
3129         <severity value="error" />
3130         <human value="All FHIR elements must have a @value or children" />
3131         <expression value="hasValue() or (children().count() > id.count())" />
3132         <xpath value="@value|f:*|h:div" />
3133         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
3134       </constraint>
3135       <isModifier value="false" />
3136       <isSummary value="true" />
3137     </element>
3138     <element id="SubstanceSpecification.relationship.isDefining">
3139       <path value="SubstanceSpecification.relationship.isDefining" />
3140       <short value="For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible substance relationships" />
3141       <definition value="For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible substance relationships." />
3142       <min value="0" />
3143       <max value="1" />
3144       <base>
3145         <path value="SubstanceSpecification.relationship.isDefining" />
3146         <min value="0" />
3147         <max value="1" />
3148       </base>
3149       <type>
3150         <code value="boolean" />
3151       </type>
3152       <constraint>
3153         <key value="ele-1" />
3154         <severity value="error" />
3155         <human value="All FHIR elements must have a @value or children" />
3156         <expression value="hasValue() or (children().count() > id.count())" />
3157         <xpath value="@value|f:*|h:div" />
3158         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
3159       </constraint>
3160       <isModifier value="false" />
3161       <isSummary value="true" />
3162     </element>
3163     <element id="SubstanceSpecification.relationship.amount[x]">
3164       <path value="SubstanceSpecification.relationship.amount[x]" />
3165       <short value="A numeric factor for the relationship, for instance to express that the salt of a substance has some percentage of the active substance in relation to some other" />
3166       <definition value="A numeric factor for the relationship, for instance to express that the salt of a substance has some percentage of the active substance in relation to some other." />
3167       <min value="0" />
3168       <max value="1" />
3169       <base>
3170         <path value="SubstanceSpecification.relationship.amount[x]" />
3171         <min value="0" />
3172         <max value="1" />
3173       </base>
3174       <type>
3175         <code value="Quantity" />
3176       </type>
3177       <type>
3178         <code value="Range" />
3179       </type>
3180       <type>
3181         <code value="Ratio" />
3182       </type>
3183       <type>
3184         <code value="string" />
3185       </type>
3186       <constraint>
3187         <key value="ele-1" />
3188         <severity value="error" />
3189         <human value="All FHIR elements must have a @value or children" />
3190         <expression value="hasValue() or (children().count() > id.count())" />
3191         <xpath value="@value|f:*|h:div" />
3192         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
3193       </constraint>
3194       <isModifier value="false" />
3195       <isSummary value="true" />
3196     </element>
3197     <element id="SubstanceSpecification.relationship.amountRatioLowLimit">
3198       <path value="SubstanceSpecification.relationship.amountRatioLowLimit" />
3199       <short value="For use when the numeric" />
3200       <definition value="For use when the numeric." />
3201       <min value="0" />
3202       <max value="1" />
3203       <base>
3204         <path value="SubstanceSpecification.relationship.amountRatioLowLimit" />
3205         <min value="0" />
3206         <max value="1" />
3207       </base>
3208       <type>
3209         <code value="Ratio" />
3210       </type>
3211       <constraint>
3212         <key value="ele-1" />
3213         <severity value="error" />
3214         <human value="All FHIR elements must have a @value or children" />
3215         <expression value="hasValue() or (children().count() > id.count())" />
3216         <xpath value="@value|f:*|h:div" />
3217         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
3218       </constraint>
3219       <isModifier value="false" />
3220       <isSummary value="true" />
3221     </element>
3222     <element id="SubstanceSpecification.relationship.amountType">
3223       <path value="SubstanceSpecification.relationship.amountType" />
3224       <short value="An operator for the amount, for example "average", "approximately", "less than"" />
3225       <definition value="An operator for the amount, for example "average", "approximately", "less than"." />
3226       <min value="0" />
3227       <max value="1" />
3228       <base>
3229         <path value="SubstanceSpecification.relationship.amountType" />
3230         <min value="0" />
3231         <max value="1" />
3232       </base>
3233       <type>
3234         <code value="CodeableConcept" />
3235       </type>
3236       <constraint>
3237         <key value="ele-1" />
3238         <severity value="error" />
3239         <human value="All FHIR elements must have a @value or children" />
3240         <expression value="hasValue() or (children().count() > id.count())" />
3241         <xpath value="@value|f:*|h:div" />
3242         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
3243       </constraint>
3244       <isModifier value="false" />
3245       <isSummary value="true" />
3246     </element>
3247     <element id="SubstanceSpecification.relationship.source">
3248       <path value="SubstanceSpecification.relationship.source" />
3249       <short value="Supporting literature" />
3250       <definition value="Supporting literature." />
3251       <min value="0" />
3252       <max value="*" />
3253       <base>
3254         <path value="SubstanceSpecification.relationship.source" />
3255         <min value="0" />
3256         <max value="*" />
3257       </base>
3258       <type>
3259         <code value="Reference" />
3260         <targetProfile value="http://hl7.org/fhir/StructureDefinition/DocumentReference" />
3261       </type>
3262       <constraint>
3263         <key value="ele-1" />
3264         <severity value="error" />
3265         <human value="All FHIR elements must have a @value or children" />
3266         <expression value="hasValue() or (children().count() > id.count())" />
3267         <xpath value="@value|f:*|h:div" />
3268         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
3269       </constraint>
3270       <isModifier value="false" />
3271       <isSummary value="true" />
3272     </element>
3273     <element id="SubstanceSpecification.nucleicAcid">
3274       <path value="SubstanceSpecification.nucleicAcid" />
3275       <short value="Data items specific to nucleic acids" />
3276       <definition value="Data items specific to nucleic acids." />
3277       <min value="0" />
3278       <max value="1" />
3279       <base>
3280         <path value="SubstanceSpecification.nucleicAcid" />
3281         <min value="0" />
3282         <max value="1" />
3283       </base>
3284       <type>
3285         <code value="Reference" />
3286         <targetProfile value="http://hl7.org/fhir/StructureDefinition/SubstanceNucleicAcid" />
3287       </type>
3288       <constraint>
3289         <key value="ele-1" />
3290         <severity value="error" />
3291         <human value="All FHIR elements must have a @value or children" />
3292         <expression value="hasValue() or (children().count() > id.count())" />
3293         <xpath value="@value|f:*|h:div" />
3294         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
3295       </constraint>
3296       <isModifier value="false" />
3297       <isSummary value="true" />
3298     </element>
3299     <element id="SubstanceSpecification.polymer">
3300       <path value="SubstanceSpecification.polymer" />
3301       <short value="Data items specific to polymers" />
3302       <definition value="Data items specific to polymers." />
3303       <min value="0" />
3304       <max value="1" />
3305       <base>
3306         <path value="SubstanceSpecification.polymer" />
3307         <min value="0" />
3308         <max value="1" />
3309       </base>
3310       <type>
3311         <code value="Reference" />
3312         <targetProfile value="http://hl7.org/fhir/StructureDefinition/SubstancePolymer" />
3313       </type>
3314       <constraint>
3315         <key value="ele-1" />
3316         <severity value="error" />
3317         <human value="All FHIR elements must have a @value or children" />
3318         <expression value="hasValue() or (children().count() > id.count())" />
3319         <xpath value="@value|f:*|h:div" />
3320         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
3321       </constraint>
3322       <isModifier value="false" />
3323       <isSummary value="true" />
3324     </element>
3325     <element id="SubstanceSpecification.protein">
3326       <path value="SubstanceSpecification.protein" />
3327       <short value="Data items specific to proteins" />
3328       <definition value="Data items specific to proteins." />
3329       <min value="0" />
3330       <max value="1" />
3331       <base>
3332         <path value="SubstanceSpecification.protein" />
3333         <min value="0" />
3334         <max value="1" />
3335       </base>
3336       <type>
3337         <code value="Reference" />
3338         <targetProfile value="http://hl7.org/fhir/StructureDefinition/SubstanceProtein" />
3339       </type>
3340       <constraint>
3341         <key value="ele-1" />
3342         <severity value="error" />
3343         <human value="All FHIR elements must have a @value or children" />
3344         <expression value="hasValue() or (children().count() > id.count())" />
3345         <xpath value="@value|f:*|h:div" />
3346         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
3347       </constraint>
3348       <isModifier value="false" />
3349       <isSummary value="true" />
3350     </element>
3351     <element id="SubstanceSpecification.sourceMaterial">
3352       <path value="SubstanceSpecification.sourceMaterial" />
3353       <short value="Material or taxonomic/anatomical source for the substance" />
3354       <definition value="Material or taxonomic/anatomical source for the substance." />
3355       <min value="0" />
3356       <max value="1" />
3357       <base>
3358         <path value="SubstanceSpecification.sourceMaterial" />
3359         <min value="0" />
3360         <max value="1" />
3361       </base>
3362       <type>
3363         <code value="Reference" />
3364         <targetProfile value="http://hl7.org/fhir/StructureDefinition/SubstanceSourceMaterial" />
3365       </type>
3366       <constraint>
3367         <key value="ele-1" />
3368         <severity value="error" />
3369         <human value="All FHIR elements must have a @value or children" />
3370         <expression value="hasValue() or (children().count() > id.count())" />
3371         <xpath value="@value|f:*|h:div" />
3372         <source value="http://hl7.org/fhir/StructureDefinition/Element" />
3373       </constraint>
3374       <isModifier value="false" />
3375       <isSummary value="true" />
3376     </element>
3377   </snapshot>
3378   <differential>
3379     <element id="SubstanceSpecification">
3380       <path value="SubstanceSpecification" />
3381       <short value="The detailed description of a substance, typically at a level beyond what is used for prescribing" />
3382       <definition value="The detailed description of a substance, typically at a level beyond what is used for prescribing." />
3383       <min value="0" />
3384       <max value="*" />
3385     </element>
3386     <element id="SubstanceSpecification.identifier">
3387       <path value="SubstanceSpecification.identifier" />
3388       <short value="Identifier by which this substance is known" />
3389       <definition value="Identifier by which this substance is known." />
3390       <min value="0" />
3391       <max value="1" />
3392       <type>
3393         <code value="Identifier" />
3394       </type>
3395       <isSummary value="true" />
3396     </element>
3397     <element id="SubstanceSpecification.type">
3398       <path value="SubstanceSpecification.type" />
3399       <short value="High level categorization, e.g. polymer or nucleic acid" />
3400       <definition value="High level categorization, e.g. polymer or nucleic acid." />
3401       <min value="0" />
3402       <max value="1" />
3403       <type>
3404         <code value="CodeableConcept" />
3405       </type>
3406       <isSummary value="true" />
3407     </element>
3408     <element id="SubstanceSpecification.status">
3409       <path value="SubstanceSpecification.status" />
3410       <short value="Status of substance within the catalogue e.g. approved" />
3411       <definition value="Status of substance within the catalogue e.g. approved." />
3412       <min value="0" />
3413       <max value="1" />
3414       <type>
3415         <code value="CodeableConcept" />
3416       </type>
3417       <isSummary value="true" />
3418     </element>
3419     <element id="SubstanceSpecification.domain">
3420       <path value="SubstanceSpecification.domain" />
3421       <short value="If the substance applies to only human or veterinary use" />
3422       <definition value="If the substance applies to only human or veterinary use." />
3423       <min value="0" />
3424       <max value="1" />
3425       <type>
3426         <code value="CodeableConcept" />
3427       </type>
3428       <isSummary value="true" />
3429     </element>
3430     <element id="SubstanceSpecification.description">
3431       <path value="SubstanceSpecification.description" />
3432       <short value="Textual description of the substance" />
3433       <definition value="Textual description of the substance." />
3434       <min value="0" />
3435       <max value="1" />
3436       <type>
3437         <code value="string" />
3438       </type>
3439       <isSummary value="true" />
3440     </element>
3441     <element id="SubstanceSpecification.source">
3442       <path value="SubstanceSpecification.source" />
3443       <short value="Supporting literature" />
3444       <definition value="Supporting literature." />
3445       <min value="0" />
3446       <max value="*" />
3447       <type>
3448         <code value="Reference" />
3449         <targetProfile value="http://hl7.org/fhir/StructureDefinition/DocumentReference" />
3450       </type>
3451       <isSummary value="true" />
3452     </element>
3453     <element id="SubstanceSpecification.comment">
3454       <path value="SubstanceSpecification.comment" />
3455       <short value="Textual comment about this record of a substance" />
3456       <definition value="Textual comment about this record of a substance." />
3457       <min value="0" />
3458       <max value="1" />
3459       <type>
3460         <code value="string" />
3461       </type>
3462       <isSummary value="true" />
3463     </element>
3464     <element id="SubstanceSpecification.moiety">
3465       <path value="SubstanceSpecification.moiety" />
3466       <short value="Moiety, for structural modifications" />
3467       <definition value="Moiety, for structural modifications." />
3468       <min value="0" />
3469       <max value="*" />
3470       <type>
3471         <code value="BackboneElement" />
3472       </type>
3473       <isSummary value="true" />
3474     </element>
3475     <element id="SubstanceSpecification.moiety.role">
3476       <path value="SubstanceSpecification.moiety.role" />
3477       <short value="Role that the moiety is playing" />
3478       <definition value="Role that the moiety is playing." />
3479       <min value="0" />
3480       <max value="1" />
3481       <type>
3482         <code value="CodeableConcept" />
3483       </type>
3484       <isSummary value="true" />
3485     </element>
3486     <element id="SubstanceSpecification.moiety.identifier">
3487       <path value="SubstanceSpecification.moiety.identifier" />
3488       <short value="Identifier by which this moiety substance is known" />
3489       <definition value="Identifier by which this moiety substance is known." />
3490       <min value="0" />
3491       <max value="1" />
3492       <type>
3493         <code value="Identifier" />
3494       </type>
3495       <isSummary value="true" />
3496     </element>
3497     <element id="SubstanceSpecification.moiety.name">
3498       <path value="SubstanceSpecification.moiety.name" />
3499       <short value="Textual name for this moiety substance" />
3500       <definition value="Textual name for this moiety substance." />
3501       <min value="0" />
3502       <max value="1" />
3503       <type>
3504         <code value="string" />
3505       </type>
3506       <isSummary value="true" />
3507     </element>
3508     <element id="SubstanceSpecification.moiety.stereochemistry">
3509       <path value="SubstanceSpecification.moiety.stereochemistry" />
3510       <short value="Stereochemistry type" />
3511       <definition value="Stereochemistry type." />
3512       <min value="0" />
3513       <max value="1" />
3514       <type>
3515         <code value="CodeableConcept" />
3516       </type>
3517       <isSummary value="true" />
3518     </element>
3519     <element id="SubstanceSpecification.moiety.opticalActivity">
3520       <path value="SubstanceSpecification.moiety.opticalActivity" />
3521       <short value="Optical activity type" />
3522       <definition value="Optical activity type." />
3523       <min value="0" />
3524       <max value="1" />
3525       <type>
3526         <code value="CodeableConcept" />
3527       </type>
3528       <isSummary value="true" />
3529     </element>
3530     <element id="SubstanceSpecification.moiety.molecularFormula">
3531       <path value="SubstanceSpecification.moiety.molecularFormula" />
3532       <short value="Molecular formula" />
3533       <definition value="Molecular formula." />
3534       <min value="0" />
3535       <max value="1" />
3536       <type>
3537         <code value="string" />
3538       </type>
3539       <isSummary value="true" />
3540     </element>
3541     <element id="SubstanceSpecification.moiety.amount[x]">
3542       <path value="SubstanceSpecification.moiety.amount[x]" />
3543       <short value="Quantitative value for this moiety" />
3544       <definition value="Quantitative value for this moiety." />
3545       <min value="0" />
3546       <max value="1" />
3547       <type>
3548         <code value="Quantity" />
3549       </type>
3550       <type>
3551         <code value="string" />
3552       </type>
3553       <isSummary value="true" />
3554     </element>
3555     <element id="SubstanceSpecification.property">
3556       <path value="SubstanceSpecification.property" />
3557       <short value="General specifications for this substance, including how it is related to other substances" />
3558       <definition value="General specifications for this substance, including how it is related to other substances." />
3559       <min value="0" />
3560       <max value="*" />
3561       <type>
3562         <code value="BackboneElement" />
3563       </type>
3564       <isSummary value="true" />
3565     </element>
3566     <element id="SubstanceSpecification.property.category">
3567       <path value="SubstanceSpecification.property.category" />
3568       <short value="A category for this property, e.g. Physical, Chemical, Enzymatic" />
3569       <definition value="A category for this property, e.g. Physical, Chemical, Enzymatic." />
3570       <min value="0" />
3571       <max value="1" />
3572       <type>
3573         <code value="CodeableConcept" />
3574       </type>
3575       <isSummary value="true" />
3576     </element>
3577     <element id="SubstanceSpecification.property.code">
3578       <path value="SubstanceSpecification.property.code" />
3579       <short value="Property type e.g. viscosity, pH, isoelectric point" />
3580       <definition value="Property type e.g. viscosity, pH, isoelectric point." />
3581       <min value="0" />
3582       <max value="1" />
3583       <type>
3584         <code value="CodeableConcept" />
3585       </type>
3586       <isSummary value="true" />
3587     </element>
3588     <element id="SubstanceSpecification.property.parameters">
3589       <path value="SubstanceSpecification.property.parameters" />
3590       <short value="Parameters that were used in the measurement of a property (e.g. for viscosity: measured at 20C with a pH of 7.1)" />
3591       <definition value="Parameters that were used in the measurement of a property (e.g. for viscosity: measured at 20C with a pH of 7.1)." />
3592       <min value="0" />
3593       <max value="1" />
3594       <type>
3595         <code value="string" />
3596       </type>
3597       <isSummary value="true" />
3598     </element>
3599     <element id="SubstanceSpecification.property.definingSubstance[x]">
3600       <path value="SubstanceSpecification.property.definingSubstance[x]" />
3601       <short value="A substance upon which a defining property depends (e.g. for solubility: in water, in alcohol)" />
3602       <definition value="A substance upon which a defining property depends (e.g. for solubility: in water, in alcohol)." />
3603       <min value="0" />
3604       <max value="1" />
3605       <type>
3606         <code value="Reference" />
3607         <targetProfile value="http://hl7.org/fhir/StructureDefinition/SubstanceSpecification" />
3608         <targetProfile value="http://hl7.org/fhir/StructureDefinition/Substance" />
3609       </type>
3610       <type>
3611         <code value="CodeableConcept" />
3612       </type>
3613       <isSummary value="true" />
3614     </element>
3615     <element id="SubstanceSpecification.property.amount[x]">
3616       <path value="SubstanceSpecification.property.amount[x]" />
3617       <short value="Quantitative value for this property" />
3618       <definition value="Quantitative value for this property." />
3619       <min value="0" />
3620       <max value="1" />
3621       <type>
3622         <code value="Quantity" />
3623       </type>
3624       <type>
3625         <code value="string" />
3626       </type>
3627       <isSummary value="true" />
3628     </element>
3629     <element id="SubstanceSpecification.referenceInformation">
3630       <path value="SubstanceSpecification.referenceInformation" />
3631       <short value="General information detailing this substance" />
3632       <definition value="General information detailing this substance." />
3633       <min value="0" />
3634       <max value="1" />
3635       <type>
3636         <code value="Reference" />
3637         <targetProfile value="http://hl7.org/fhir/StructureDefinition/SubstanceReferenceInformation" />
3638       </type>
3639       <isSummary value="true" />
3640     </element>
3641     <element id="SubstanceSpecification.structure">
3642       <path value="SubstanceSpecification.structure" />
3643       <short value="Structural information" />
3644       <definition value="Structural information." />
3645       <min value="0" />
3646       <max value="1" />
3647       <type>
3648         <code value="BackboneElement" />
3649       </type>
3650       <isSummary value="true" />
3651     </element>
3652     <element id="SubstanceSpecification.structure.stereochemistry">
3653       <path value="SubstanceSpecification.structure.stereochemistry" />
3654       <short value="Stereochemistry type" />
3655       <definition value="Stereochemistry type." />
3656       <min value="0" />
3657       <max value="1" />
3658       <type>
3659         <code value="CodeableConcept" />
3660       </type>
3661       <isSummary value="true" />
3662     </element>
3663     <element id="SubstanceSpecification.structure.opticalActivity">
3664       <path value="SubstanceSpecification.structure.opticalActivity" />
3665       <short value="Optical activity type" />
3666       <definition value="Optical activity type." />
3667       <min value="0" />
3668       <max value="1" />
3669       <type>
3670         <code value="CodeableConcept" />
3671       </type>
3672       <isSummary value="true" />
3673     </element>
3674     <element id="SubstanceSpecification.structure.molecularFormula">
3675       <path value="SubstanceSpecification.structure.molecularFormula" />
3676       <short value="Molecular formula" />
3677       <definition value="Molecular formula." />
3678       <min value="0" />
3679       <max value="1" />
3680       <type>
3681         <code value="string" />
3682       </type>
3683       <isSummary value="true" />
3684     </element>
3685     <element id="SubstanceSpecification.structure.molecularFormulaByMoiety">
3686       <path value="SubstanceSpecification.structure.molecularFormulaByMoiety" />
3687       <short value="Specified per moiety according to the Hill system, i.e. first C, then H, then alphabetical, each moiety separated by a dot" />
3688       <definition value="Specified per moiety according to the Hill system, i.e. first C, then H, then alphabetical, each moiety separated by a dot." />
3689       <min value="0" />
3690       <max value="1" />
3691       <type>
3692         <code value="string" />
3693       </type>
3694       <isSummary value="true" />
3695     </element>
3696     <element id="SubstanceSpecification.structure.isotope">
3697       <path value="SubstanceSpecification.structure.isotope" />
3698       <short value="Applicable for single substances that contain a radionuclide or a non-natural isotopic ratio" />
3699       <definition value="Applicable for single substances that contain a radionuclide or a non-natural isotopic ratio." />
3700       <min value="0" />
3701       <max value="*" />
3702       <type>
3703         <code value="BackboneElement" />
3704       </type>
3705       <isSummary value="true" />
3706     </element>
3707     <element id="SubstanceSpecification.structure.isotope.identifier">
3708       <path value="SubstanceSpecification.structure.isotope.identifier" />
3709       <short value="Substance identifier for each non-natural or radioisotope" />
3710       <definition value="Substance identifier for each non-natural or radioisotope." />
3711       <min value="0" />
3712       <max value="1" />
3713       <type>
3714         <code value="Identifier" />
3715       </type>
3716       <isSummary value="true" />
3717     </element>
3718     <element id="SubstanceSpecification.structure.isotope.name">
3719       <path value="SubstanceSpecification.structure.isotope.name" />
3720       <short value="Substance name for each non-natural or radioisotope" />
3721       <definition value="Substance name for each non-natural or radioisotope." />
3722       <min value="0" />
3723       <max value="1" />
3724       <type>
3725         <code value="CodeableConcept" />
3726       </type>
3727       <isSummary value="true" />
3728     </element>
3729     <element id="SubstanceSpecification.structure.isotope.substitution">
3730       <path value="SubstanceSpecification.structure.isotope.substitution" />
3731       <short value="The type of isotopic substitution present in a single substance" />
3732       <definition value="The type of isotopic substitution present in a single substance." />
3733       <min value="0" />
3734       <max value="1" />
3735       <type>
3736         <code value="CodeableConcept" />
3737       </type>
3738       <isSummary value="true" />
3739     </element>
3740     <element id="SubstanceSpecification.structure.isotope.halfLife">
3741       <path value="SubstanceSpecification.structure.isotope.halfLife" />
3742       <short value="Half life - for a non-natural nuclide" />
3743       <definition value="Half life - for a non-natural nuclide." />
3744       <min value="0" />
3745       <max value="1" />
3746       <type>
3747         <code value="Quantity" />
3748       </type>
3749       <isSummary value="true" />
3750     </element>
3751     <element id="SubstanceSpecification.structure.isotope.molecularWeight">
3752       <path value="SubstanceSpecification.structure.isotope.molecularWeight" />
3753       <short value="The molecular weight or weight range (for proteins, polymers or nucleic acids)" />
3754       <definition value="The molecular weight or weight range (for proteins, polymers or nucleic acids)." />
3755       <min value="0" />
3756       <max value="1" />
3757       <type>
3758         <code value="BackboneElement" />
3759       </type>
3760       <isSummary value="true" />
3761     </element>
3762     <element id="SubstanceSpecification.structure.isotope.molecularWeight.method">
3763       <path value="SubstanceSpecification.structure.isotope.molecularWeight.method" />
3764       <short value="The method by which the molecular weight was determined" />
3765       <definition value="The method by which the molecular weight was determined." />
3766       <min value="0" />
3767       <max value="1" />
3768       <type>
3769         <code value="CodeableConcept" />
3770       </type>
3771       <isSummary value="true" />
3772     </element>
3773     <element id="SubstanceSpecification.structure.isotope.molecularWeight.type">
3774       <path value="SubstanceSpecification.structure.isotope.molecularWeight.type" />
3775       <short value="Type of molecular weight such as exact, average (also known as. number average), weight average" />
3776       <definition value="Type of molecular weight such as exact, average (also known as. number average), weight average." />
3777       <min value="0" />
3778       <max value="1" />
3779       <type>
3780         <code value="CodeableConcept" />
3781       </type>
3782       <isSummary value="true" />
3783     </element>
3784     <element id="SubstanceSpecification.structure.isotope.molecularWeight.amount">
3785       <path value="SubstanceSpecification.structure.isotope.molecularWeight.amount" />
3786       <short value="Used to capture quantitative values for a variety of elements. If only limits are given, the arithmetic mean would be the average. If only a single definite value for a given element is given, it would be captured in this field" />
3787       <definition value="Used to capture quantitative values for a variety of elements. If only limits are given, the arithmetic mean would be the average. If only a single definite value for a given element is given, it would be captured in this field." />
3788       <min value="0" />
3789       <max value="1" />
3790       <type>
3791         <code value="Quantity" />
3792       </type>
3793       <isSummary value="true" />
3794     </element>
3795     <element id="SubstanceSpecification.structure.molecularWeight">
3796       <path value="SubstanceSpecification.structure.molecularWeight" />
3797       <short value="The molecular weight or weight range (for proteins, polymers or nucleic acids)" />
3798       <definition value="The molecular weight or weight range (for proteins, polymers or nucleic acids)." />
3799       <min value="0" />
3800       <max value="1" />
3801       <contentReference value="#SubstanceSpecification.structure.isotope.molecularWeight" />
3802       <isSummary value="true" />
3803     </element>
3804     <element id="SubstanceSpecification.structure.source">
3805       <path value="SubstanceSpecification.structure.source" />
3806       <short value="Supporting literature" />
3807       <definition value="Supporting literature." />
3808       <min value="0" />
3809       <max value="*" />
3810       <type>
3811         <code value="Reference" />
3812         <targetProfile value="http://hl7.org/fhir/StructureDefinition/DocumentReference" />
3813       </type>
3814       <isSummary value="true" />
3815     </element>
3816     <element id="SubstanceSpecification.structure.representation">
3817       <path value="SubstanceSpecification.structure.representation" />
3818       <short value="Molecular structural representation" />
3819       <definition value="Molecular structural representation." />
3820       <min value="0" />
3821       <max value="*" />
3822       <type>
3823         <code value="BackboneElement" />
3824       </type>
3825       <isSummary value="true" />
3826     </element>
3827     <element id="SubstanceSpecification.structure.representation.type">
3828       <path value="SubstanceSpecification.structure.representation.type" />
3829       <short value="The type of structure (e.g. Full, Partial, Representative)" />
3830       <definition value="The type of structure (e.g. Full, Partial, Representative)." />
3831       <min value="0" />
3832       <max value="1" />
3833       <type>
3834         <code value="CodeableConcept" />
3835       </type>
3836       <isSummary value="true" />
3837     </element>
3838     <element id="SubstanceSpecification.structure.representation.representation">
3839       <path value="SubstanceSpecification.structure.representation.representation" />
3840       <short value="The structural representation as text string in a format e.g. InChI, SMILES, MOLFILE, CDX" />
3841       <definition value="The structural representation as text string in a format e.g. InChI, SMILES, MOLFILE, CDX." />
3842       <min value="0" />
3843       <max value="1" />
3844       <type>
3845         <code value="string" />
3846       </type>
3847       <isSummary value="true" />
3848     </element>
3849     <element id="SubstanceSpecification.structure.representation.attachment">
3850       <path value="SubstanceSpecification.structure.representation.attachment" />
3851       <short value="An attached file with the structural representation" />
3852       <definition value="An attached file with the structural representation." />
3853       <min value="0" />
3854       <max value="1" />
3855       <type>
3856         <code value="Attachment" />
3857       </type>
3858       <isSummary value="true" />
3859     </element>
3860     <element id="SubstanceSpecification.code">
3861       <path value="SubstanceSpecification.code" />
3862       <short value="Codes associated with the substance" />
3863       <definition value="Codes associated with the substance." />
3864       <min value="0" />
3865       <max value="*" />
3866       <type>
3867         <code value="BackboneElement" />
3868       </type>
3869       <isSummary value="true" />
3870     </element>
3871     <element id="SubstanceSpecification.code.code">
3872       <path value="SubstanceSpecification.code.code" />
3873       <short value="The specific code" />
3874       <definition value="The specific code." />
3875       <min value="0" />
3876       <max value="1" />
3877       <type>
3878         <code value="CodeableConcept" />
3879       </type>
3880       <isSummary value="true" />
3881     </element>
3882     <element id="SubstanceSpecification.code.status">
3883       <path value="SubstanceSpecification.code.status" />
3884       <short value="Status of the code assignment" />
3885       <definition value="Status of the code assignment." />
3886       <min value="0" />
3887       <max value="1" />
3888       <type>
3889         <code value="CodeableConcept" />
3890       </type>
3891       <isSummary value="true" />
3892     </element>
3893     <element id="SubstanceSpecification.code.statusDate">
3894       <path value="SubstanceSpecification.code.statusDate" />
3895       <short value="The date at which the code status is changed as part of the terminology maintenance" />
3896       <definition value="The date at which the code status is changed as part of the terminology maintenance." />
3897       <min value="0" />
3898       <max value="1" />
3899       <type>
3900         <code value="dateTime" />
3901       </type>
3902       <isSummary value="true" />
3903     </element>
3904     <element id="SubstanceSpecification.code.comment">
3905       <path value="SubstanceSpecification.code.comment" />
3906       <short value="Any comment can be provided in this field, if necessary" />
3907       <definition value="Any comment can be provided in this field, if necessary." />
3908       <min value="0" />
3909       <max value="1" />
3910       <type>
3911         <code value="string" />
3912       </type>
3913       <isSummary value="true" />
3914     </element>
3915     <element id="SubstanceSpecification.code.source">
3916       <path value="SubstanceSpecification.code.source" />
3917       <short value="Supporting literature" />
3918       <definition value="Supporting literature." />
3919       <min value="0" />
3920       <max value="*" />
3921       <type>
3922         <code value="Reference" />
3923         <targetProfile value="http://hl7.org/fhir/StructureDefinition/DocumentReference" />
3924       </type>
3925       <isSummary value="true" />
3926     </element>
3927     <element id="SubstanceSpecification.name">
3928       <path value="SubstanceSpecification.name" />
3929       <short value="Names applicable to this substance" />
3930       <definition value="Names applicable to this substance." />
3931       <min value="0" />
3932       <max value="*" />
3933       <type>
3934         <code value="BackboneElement" />
3935       </type>
3936       <isSummary value="true" />
3937     </element>
3938     <element id="SubstanceSpecification.name.name">
3939       <path value="SubstanceSpecification.name.name" />
3940       <short value="The actual name" />
3941       <definition value="The actual name." />
3942       <min value="1" />
3943       <max value="1" />
3944       <type>
3945         <code value="string" />
3946       </type>
3947       <isSummary value="true" />
3948     </element>
3949     <element id="SubstanceSpecification.name.type">
3950       <path value="SubstanceSpecification.name.type" />
3951       <short value="Name type" />
3952       <definition value="Name type." />
3953       <min value="0" />
3954       <max value="1" />
3955       <type>
3956         <code value="CodeableConcept" />
3957       </type>
3958       <isSummary value="true" />
3959     </element>
3960     <element id="SubstanceSpecification.name.status">
3961       <path value="SubstanceSpecification.name.status" />
3962       <short value="The status of the name" />
3963       <definition value="The status of the name." />
3964       <min value="0" />
3965       <max value="1" />
3966       <type>
3967         <code value="CodeableConcept" />
3968       </type>
3969       <isSummary value="true" />
3970     </element>
3971     <element id="SubstanceSpecification.name.preferred">
3972       <path value="SubstanceSpecification.name.preferred" />
3973       <short value="If this is the preferred name for this substance" />
3974       <definition value="If this is the preferred name for this substance." />
3975       <min value="0" />
3976       <max value="1" />
3977       <type>
3978         <code value="boolean" />
3979       </type>
3980       <isSummary value="true" />
3981     </element>
3982     <element id="SubstanceSpecification.name.language">
3983       <path value="SubstanceSpecification.name.language" />
3984       <short value="Language of the name" />
3985       <definition value="Language of the name." />
3986       <min value="0" />
3987       <max value="*" />
3988       <type>
3989         <code value="CodeableConcept" />
3990       </type>
3991       <isSummary value="true" />
3992     </element>
3993     <element id="SubstanceSpecification.name.domain">
3994       <path value="SubstanceSpecification.name.domain" />
3995       <short value="The use context of this name for example if there is a different name a drug active ingredient as opposed to a food colour additive" />
3996       <definition value="The use context of this name for example if there is a different name a drug active ingredient as opposed to a food colour additive." />
3997       <min value="0" />
3998       <max value="*" />
3999       <type>
4000         <code value="CodeableConcept" />
4001       </type>
4002       <isSummary value="true" />
4003     </element>
4004     <element id="SubstanceSpecification.name.jurisdiction">
4005       <path value="SubstanceSpecification.name.jurisdiction" />
4006       <short value="The jurisdiction where this name applies" />
4007       <definition value="The jurisdiction where this name applies." />
4008       <min value="0" />
4009       <max value="*" />
4010       <type>
4011         <code value="CodeableConcept" />
4012       </type>
4013       <isSummary value="true" />
4014     </element>
4015     <element id="SubstanceSpecification.name.synonym">
4016       <path value="SubstanceSpecification.name.synonym" />
4017       <short value="A synonym of this name" />
4018       <definition value="A synonym of this name." />
4019       <min value="0" />
4020       <max value="*" />
4021       <contentReference value="#SubstanceSpecification.name" />
4022       <isSummary value="true" />
4023     </element>
4024     <element id="SubstanceSpecification.name.translation">
4025       <path value="SubstanceSpecification.name.translation" />
4026       <short value="A translation for this name" />
4027       <definition value="A translation for this name." />
4028       <min value="0" />
4029       <max value="*" />
4030       <contentReference value="#SubstanceSpecification.name" />
4031       <isSummary value="true" />
4032     </element>
4033     <element id="SubstanceSpecification.name.official">
4034       <path value="SubstanceSpecification.name.official" />
4035       <short value="Details of the official nature of this name" />
4036       <definition value="Details of the official nature of this name." />
4037       <min value="0" />
4038       <max value="*" />
4039       <type>
4040         <code value="BackboneElement" />
4041       </type>
4042       <isSummary value="true" />
4043     </element>
4044     <element id="SubstanceSpecification.name.official.authority">
4045       <path value="SubstanceSpecification.name.official.authority" />
4046       <short value="Which authority uses this official name" />
4047       <definition value="Which authority uses this official name." />
4048       <min value="0" />
4049       <max value="1" />
4050       <type>
4051         <code value="CodeableConcept" />
4052       </type>
4053       <isSummary value="true" />
4054     </element>
4055     <element id="SubstanceSpecification.name.official.status">
4056       <path value="SubstanceSpecification.name.official.status" />
4057       <short value="The status of the official name" />
4058       <definition value="The status of the official name." />
4059       <min value="0" />
4060       <max value="1" />
4061       <type>
4062         <code value="CodeableConcept" />
4063       </type>
4064       <isSummary value="true" />
4065     </element>
4066     <element id="SubstanceSpecification.name.official.date">
4067       <path value="SubstanceSpecification.name.official.date" />
4068       <short value="Date of official name change" />
4069       <definition value="Date of official name change." />
4070       <min value="0" />
4071       <max value="1" />
4072       <type>
4073         <code value="dateTime" />
4074       </type>
4075       <isSummary value="true" />
4076     </element>
4077     <element id="SubstanceSpecification.name.source">
4078       <path value="SubstanceSpecification.name.source" />
4079       <short value="Supporting literature" />
4080       <definition value="Supporting literature." />
4081       <min value="0" />
4082       <max value="*" />
4083       <type>
4084         <code value="Reference" />
4085         <targetProfile value="http://hl7.org/fhir/StructureDefinition/DocumentReference" />
4086       </type>
4087       <isSummary value="true" />
4088     </element>
4089     <element id="SubstanceSpecification.molecularWeight">
4090       <path value="SubstanceSpecification.molecularWeight" />
4091       <short value="The molecular weight or weight range (for proteins, polymers or nucleic acids)" />
4092       <definition value="The molecular weight or weight range (for proteins, polymers or nucleic acids)." />
4093       <min value="0" />
4094       <max value="*" />
4095       <contentReference value="#SubstanceSpecification.structure.isotope.molecularWeight" />
4096       <isSummary value="true" />
4097     </element>
4098     <element id="SubstanceSpecification.relationship">
4099       <path value="SubstanceSpecification.relationship" />
4100       <short value="A link between this substance and another, with details of the relationship" />
4101       <definition value="A link between this substance and another, with details of the relationship." />
4102       <min value="0" />
4103       <max value="*" />
4104       <type>
4105         <code value="BackboneElement" />
4106       </type>
4107       <isSummary value="true" />
4108     </element>
4109     <element id="SubstanceSpecification.relationship.substance[x]">
4110       <path value="SubstanceSpecification.relationship.substance[x]" />
4111       <short value="A pointer to another substance, as a resource or just a representational code" />
4112       <definition value="A pointer to another substance, as a resource or just a representational code." />
4113       <min value="0" />
4114       <max value="1" />
4115       <type>
4116         <code value="Reference" />
4117         <targetProfile value="http://hl7.org/fhir/StructureDefinition/SubstanceSpecification" />
4118       </type>
4119       <type>
4120         <code value="CodeableConcept" />
4121       </type>
4122       <isSummary value="true" />
4123     </element>
4124     <element id="SubstanceSpecification.relationship.relationship">
4125       <path value="SubstanceSpecification.relationship.relationship" />
4126       <short value="For example "salt to parent", "active moiety", "starting material"" />
4127       <definition value="For example "salt to parent", "active moiety", "starting material"." />
4128       <min value="0" />
4129       <max value="1" />
4130       <type>
4131         <code value="CodeableConcept" />
4132       </type>
4133       <isSummary value="true" />
4134     </element>
4135     <element id="SubstanceSpecification.relationship.isDefining">
4136       <path value="SubstanceSpecification.relationship.isDefining" />
4137       <short value="For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible substance relationships" />
4138       <definition value="For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible substance relationships." />
4139       <min value="0" />
4140       <max value="1" />
4141       <type>
4142         <code value="boolean" />
4143       </type>
4144       <isSummary value="true" />
4145     </element>
4146     <element id="SubstanceSpecification.relationship.amount[x]">
4147       <path value="SubstanceSpecification.relationship.amount[x]" />
4148       <short value="A numeric factor for the relationship, for instance to express that the salt of a substance has some percentage of the active substance in relation to some other" />
4149       <definition value="A numeric factor for the relationship, for instance to express that the salt of a substance has some percentage of the active substance in relation to some other." />
4150       <min value="0" />
4151       <max value="1" />
4152       <type>
4153         <code value="Quantity" />
4154       </type>
4155       <type>
4156         <code value="Range" />
4157       </type>
4158       <type>
4159         <code value="Ratio" />
4160       </type>
4161       <type>
4162         <code value="string" />
4163       </type>
4164       <isSummary value="true" />
4165     </element>
4166     <element id="SubstanceSpecification.relationship.amountRatioLowLimit">
4167       <path value="SubstanceSpecification.relationship.amountRatioLowLimit" />
4168       <short value="For use when the numeric" />
4169       <definition value="For use when the numeric." />
4170       <min value="0" />
4171       <max value="1" />
4172       <type>
4173         <code value="Ratio" />
4174       </type>
4175       <isSummary value="true" />
4176     </element>
4177     <element id="SubstanceSpecification.relationship.amountType">
4178       <path value="SubstanceSpecification.relationship.amountType" />
4179       <short value="An operator for the amount, for example "average", "approximately", "less than"" />
4180       <definition value="An operator for the amount, for example "average", "approximately", "less than"." />
4181       <min value="0" />
4182       <max value="1" />
4183       <type>
4184         <code value="CodeableConcept" />
4185       </type>
4186       <isSummary value="true" />
4187     </element>
4188     <element id="SubstanceSpecification.relationship.source">
4189       <path value="SubstanceSpecification.relationship.source" />
4190       <short value="Supporting literature" />
4191       <definition value="Supporting literature." />
4192       <min value="0" />
4193       <max value="*" />
4194       <type>
4195         <code value="Reference" />
4196         <targetProfile value="http://hl7.org/fhir/StructureDefinition/DocumentReference" />
4197       </type>
4198       <isSummary value="true" />
4199     </element>
4200     <element id="SubstanceSpecification.nucleicAcid">
4201       <path value="SubstanceSpecification.nucleicAcid" />
4202       <short value="Data items specific to nucleic acids" />
4203       <definition value="Data items specific to nucleic acids." />
4204       <min value="0" />
4205       <max value="1" />
4206       <type>
4207         <code value="Reference" />
4208         <targetProfile value="http://hl7.org/fhir/StructureDefinition/SubstanceNucleicAcid" />
4209       </type>
4210       <isSummary value="true" />
4211     </element>
4212     <element id="SubstanceSpecification.polymer">
4213       <path value="SubstanceSpecification.polymer" />
4214       <short value="Data items specific to polymers" />
4215       <definition value="Data items specific to polymers." />
4216       <min value="0" />
4217       <max value="1" />
4218       <type>
4219         <code value="Reference" />
4220         <targetProfile value="http://hl7.org/fhir/StructureDefinition/SubstancePolymer" />
4221       </type>
4222       <isSummary value="true" />
4223     </element>
4224     <element id="SubstanceSpecification.protein">
4225       <path value="SubstanceSpecification.protein" />
4226       <short value="Data items specific to proteins" />
4227       <definition value="Data items specific to proteins." />
4228       <min value="0" />
4229       <max value="1" />
4230       <type>
4231         <code value="Reference" />
4232         <targetProfile value="http://hl7.org/fhir/StructureDefinition/SubstanceProtein" />
4233       </type>
4234       <isSummary value="true" />
4235     </element>
4236     <element id="SubstanceSpecification.sourceMaterial">
4237       <path value="SubstanceSpecification.sourceMaterial" />
4238       <short value="Material or taxonomic/anatomical source for the substance" />
4239       <definition value="Material or taxonomic/anatomical source for the substance." />
4240       <min value="0" />
4241       <max value="1" />
4242       <type>
4243         <code value="Reference" />
4244         <targetProfile value="http://hl7.org/fhir/StructureDefinition/SubstanceSourceMaterial" />
4245       </type>
4246       <isSummary value="true" />
4247     </element>
4248   </differential>
4249 </StructureDefinition>